Assessment of the visual pathways in patients with neurofibromatosis-1 by 3S-space technique with 3-Tesla MRI

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buir.contributor.authorAlgın, Oktay
dc.citation.epage1633en_US
dc.citation.issueNumber6en_US
dc.citation.spage1626en_US
dc.citation.volumeNumber49en_US
dc.contributor.authorSaraç, Ö.en_US
dc.contributor.authorAlgın, Oktayen_US
dc.contributor.authorBeyazal, M.en_US
dc.contributor.authorAnlar, B.en_US
dc.contributor.authorVaran, A.en_US
dc.contributor.authorKansu, T.en_US
dc.date.accessioned2020-02-24T08:12:20Z
dc.date.available2020-02-24T08:12:20Z
dc.date.issued2019-12
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.description.abstractBackground/aim: We aimed to evaluate the size/tortuosity of the optic nerve (ON) and the dilatation of the ON sheath (ONS) in neurofibromatosis type 1 (NF-1) patients with 3T-MRI, and to assess the usefulness of 3D-SPACE in imaging the optic pathway, ON, and ONS in NF-1 patients. Materials and methods: Twenty consecutive NF-1 patients without optic pathway glioma (OPG) (Group 1), 16 consecutive NF-1 patients with OPG (Group 2), and 19 controls were included in this study. The thickness and tortuosity of the ON and the diameter of the ONS were measured on STIR and 3D-SPACE images. Results: The thickness of the ON was similar in all groups on STIR images (P>0.05). The mean ONS diameter was higher in Group 2 with this sequence (P=0.009). Controls had significantly lower grades of ON tortuosity than Groups 1 and 2 (P=0.001), and Group 1 had significantly lower ON tortuosity compared to Group 2 (P=0.001). Severe tortuosity was only detected in Group 2. Conclusion: ON tortuosity and ONS diameter were increased in NF-1 patients in the presence of OPG. High-resolution cranium imaging with the 3D-SPACE technique using 3T-MRI seems to be helpful for detection of the optic pathway morphology and pathologies in NF-1 patients.en_US
dc.identifier.doi10.3906/sag-1906-14en_US
dc.identifier.issn1300-0144
dc.identifier.urihttp://hdl.handle.net/11693/53479
dc.language.isoEnglishen_US
dc.publisherTÜBİTAKen_US
dc.relation.isversionofhttps://dx.doi.org/10.3906/sag-1906-14en_US
dc.source.titleTurkish Journal of Medical Sciencesen_US
dc.subjectNeurofibromatosis type 1en_US
dc.subjectOptic pathway gliomaen_US
dc.subject3D-SPACEen_US
dc.subjectOptic nerve thicknessen_US
dc.subjectOptic nerve sheath diameteren_US
dc.subjectOptic nerve tortuosityen_US
dc.titleAssessment of the visual pathways in patients with neurofibromatosis-1 by 3S-space technique with 3-Tesla MRIen_US
dc.typeArticleen_US

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