Microwave resonant sensor integration with impedance cytometry in microfluidic platform for probing micro-scale dielectric permittivity

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buir.advisorHanay, Mehmet Selim
dc.contributor.authorTefek, Uzay
dc.date.accessioned2023-09-22T10:57:42Z
dc.date.available2023-09-22T10:57:42Z
dc.date.copyright2023-09
dc.date.issued2023-09
dc.date.submitted2023-09-19
dc.departmentDepartment of Mechanical Engineering
dc.descriptionCataloged from PDF version of article.
dc.descriptionThesis (Master's): Bilkent University, Mechanical Engineering, İhsan Doğramacı Bilkent University, 2023.
dc.descriptionIncludes bibliographical references (leaves 72-76).
dc.description.abstractThis thesis presents a novel multiphysical sensor that integrates low-frequency impedance cytometry with high-frequency microwave capacitance sensing. The characterization of microscale objects, including microparticles and cells, is essential in various scientific disciplines, such as biology, materials science, and environmental science. Accurate identification and classification of these microscale entities are critical for applications ranging from drug delivery optimization to environmental impact assessment, however, the current techniques fall short in terms of the rapidity and cost-effectiveness necessary for analyzing extensive populations. To address this challenge, our hybrid sensor combines low-frequency impedance cytometry and high-frequency microwave capacitance sensing for material characterization based on dielectric permittivity. This integration offers a rapid, cost-effective, and highly accurate method for identifying and characterizing microscale particles and cells. Experimental studies demonstrate the sensor’s efficacy, achieving remarkable signal-to-noise ratios. The sensor’s versatility ex-tends monitoring permittivity changes in single cells exposed to fixing agents offering valuable insights into cellular properties. In summary, this thesis introduces an innovative multiphysical sensor that advances microscale entity analysis, enabling rapid and precise identification and characterization.
dc.description.degreeM.S.
dc.description.statementofresponsibilityby Uzay Tefek
dc.embargo.release2025-09-01
dc.format.extentxii, 76 leaves : color illustrations, charts ; 30 cm.
dc.identifier.itemidB162534
dc.identifier.urihttps://hdl.handle.net/11693/113894
dc.language.isoEnglish
dc.publisherBilkent University
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectImpedance cytometry
dc.subjectMicrowave sensors
dc.subjectMicroplastics
dc.subjectMicroparticles
dc.subjectDielectric characterization
dc.subjectMicrowave resonators
dc.subjectClausius-mossotti factor
dc.titleMicrowave resonant sensor integration with impedance cytometry in microfluidic platform for probing micro-scale dielectric permittivity
dc.title.alternativeMikro ölçekte dielektrik geçirgenliği incelemek için mikroakışkan platformda empedans sitometri ile mikrodalga rezonans sensörünün entegrasyonu
dc.typeThesis

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Dept. of Mechanical Engineering - Master's degree