Expression of TAP73 and ΔNP73 in malignant gliomas

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dc.citation.epage1341en_US
dc.citation.issueNumber6en_US
dc.citation.spage1337en_US
dc.citation.volumeNumber11en_US
dc.contributor.authorUgur, H.en_US
dc.contributor.authorSayan, A. E.en_US
dc.contributor.authorOzdamar, S. O.en_US
dc.contributor.authorKanpolat, Y.en_US
dc.contributor.authorOzturk, M.en_US
dc.date.accessioned2016-02-08T10:26:50Z
dc.date.available2016-02-08T10:26:50Z
dc.date.issued2004en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractThe p73 gene is able to encode transcriptionaly active TAp73, as well as a dominant-negatively acting ΔNp73 transcript isoforms. We studied differential expression of these forms in normal brain as well as glial tumors, by semiquantitative RT-PCR. The expression of p73 was low or undetectable in normal brain tissues. Most of the tumors and non-tumor brain tissues also lacked significant expression of p73 in patients with low-grade astrocytomas. In contrast, most high-grade glial tumors displayed strong upregulation of TAp73, whereas only a few displayed ΔNp73 expression. These aberrations may reflect the inactivation of retinoblastoma pathway in these tumors which result in the activation of E2F transcription factors, since TAp73 is a known target of E2F1 gene. The study of TAp73 expression in brain tumors may serve as a means to evaluate the retinoblastoma pathway-dependent tumor progression.en_US
dc.identifier.issn1021-335X
dc.identifier.urihttp://hdl.handle.net/11693/24278
dc.language.isoEnglishen_US
dc.publisherSpandidos Publications Ltd.en_US
dc.source.titleOncology Reportsen_US
dc.subjectBrain tumoren_US
dc.subjectDominant negative p73en_US
dc.subjectGlial tumoren_US
dc.subjectp73en_US
dc.subjectRetinoblastoma pathwayen_US
dc.subjectTranscriptionally active p73en_US
dc.subjectTumor progressionen_US
dc.subjectDNA binding proteinen_US
dc.titleExpression of TAP73 and ΔNP73 in malignant gliomasen_US
dc.typeArticleen_US

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