Generation of singlet oxygen by persistent luminescent nanoparticle-photosensitizer conjugates: a proof of principle for photodynamic therapy without light

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dc.citation.epage187en_US
dc.citation.issueNumber5en_US
dc.citation.spage183en_US
dc.citation.volumeNumber1en_US
dc.contributor.authorOzdemir, T.en_US
dc.contributor.authorLu, Y. C.en_US
dc.contributor.authorKolemen, S.en_US
dc.contributor.authorTanriverdi-Ecik, E.en_US
dc.contributor.authorAkkaya, E. U.en_US
dc.date.accessioned2019-02-05T11:44:05Z
dc.date.available2019-02-05T11:44:05Z
dc.date.issued2017en_US
dc.departmentDepartment of Chemistryen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractThe broader application of photodynamic therapy as a treatment procedure for cancer is hampered by the limited penetration of light through mammalian tissues. Since the photosensitized generation of cytotoxic singlet oxygen requires effective excitation of the tumor-localized photosensitizer, photodynamic action can only be guaranteed for the first few millimeters of the irradiated tissues. In this work, we demonstrated that the phenomenon of persistent luminescence, that is, delayed emission from certain metal-ion excited states (with crystal defects acting as energy traps), can provide an alternative excitation possibility. Thus, persistent luminescent nanoparticles functionalized by FRET-matching Bodipy sensitizers (FRET=Fçrster resonance energy transfer) were excited in situ before administration into a cell culture or an organism. It was found that this system continues to produce singlet oxygen regardless of their location and without any need for continuous photonic excitation.en_US
dc.description.provenanceSubmitted by Esma Babayiğit (esma.babayigit@bilkent.edu.tr) on 2019-02-05T11:44:05Z No. of bitstreams: 1 Generation_of_singlet_oxygen_by_persistent_luminescent_nanoparticle_photosensitizer_conjugates_a_proof_of_principle_for_photodynamic_therapy_without_light.pdf: 1156609 bytes, checksum: 90b50de61e483a14e3a3775f9a214e73 (MD5)en
dc.description.provenanceMade available in DSpace on 2019-02-05T11:44:05Z (GMT). No. of bitstreams: 1 Generation_of_singlet_oxygen_by_persistent_luminescent_nanoparticle_photosensitizer_conjugates_a_proof_of_principle_for_photodynamic_therapy_without_light.pdf: 1156609 bytes, checksum: 90b50de61e483a14e3a3775f9a214e73 (MD5) Previous issue date: 2017en
dc.embargo.release2018-05-15en_US
dc.identifier.doi10.1002/cptc.201600049en_US
dc.identifier.issn2367-0932
dc.identifier.urihttp://hdl.handle.net/11693/48882
dc.language.isoEnglishen_US
dc.publisherWiley - VCH Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/cptc.201600049en_US
dc.source.titleChemPhotoChemen_US
dc.titleGeneration of singlet oxygen by persistent luminescent nanoparticle-photosensitizer conjugates: a proof of principle for photodynamic therapy without lighten_US
dc.typeArticleen_US

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