Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats

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buir.contributor.authorAdams, Michelle M.
dc.citation.epage1949en_US
dc.citation.issueNumber9en_US
dc.citation.spage1938en_US
dc.citation.volumeNumber33en_US
dc.contributor.authorMolina, D. P.en_US
dc.contributor.authorAriwodola, O. J.en_US
dc.contributor.authorLinville, C.en_US
dc.contributor.authorSonntag, W. E.en_US
dc.contributor.authorWeiner, J. L.en_US
dc.contributor.authorBrunso-Bechtold, J. K.en_US
dc.contributor.authorAdams, Michelle M.en_US
dc.date.accessioned2016-02-08T09:45:03Z
dc.date.available2016-02-08T09:45:03Z
dc.date.issued2012en_US
dc.departmentDepartment of Psychologyen_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.description.abstractAlterations in the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPA-R) and N-methyl-D-aspartate receptor (NMDA-R) have been documented in aged animals and may contribute to changes in hippocampal-dependent memory. Growth hormone (GH) regulates AMPA-R and NMDA-R-dependent excitatory transmission and decreases with age. Chronic GH treatment mitigates age-related cognitive decline. An in vitro CA1 hippocampal slice preparation was used to compare hippocampal excitatory transmission and plasticity in old animals treated for 6-8 months with either saline or GH. Our findings indicate that GH treatment restores NMDA-R-dependent basal synaptic transmission in old rats to young adult levels and enhances both AMPA-R-dependent basal synaptic transmission and long-term potentiation. These alterations in synaptic function occurred in the absence of changes in presynaptic function, as measured by paired-pulse ratios, the total protein levels of AMPA-R and NMDA-R subunits or in plasma or hippocampal levels of insulin-like growth factor-I. These data suggest a direct role for GH in altering age-related changes in excitatory transmission and provide a possible cellular mechanism through which GH changes the course of cognitive decline. © 2012 Elsevier Inc.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:45:03Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2012en
dc.identifier.doi10.1016/j.neurobiolaging.2011.09.014en_US
dc.identifier.issn0197-4580
dc.identifier.urihttp://hdl.handle.net/11693/21345
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.09.014en_US
dc.source.titleNeurobiology of Agingen_US
dc.subjectLong-term potentiationen_US
dc.subjectPaired-pulse ratiosen_US
dc.subjectInput-output curvesen_US
dc.subjectAMPA receptoren_US
dc.subjectNMDA receptoren_US
dc.titleGrowth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old ratsen_US
dc.typeArticleen_US

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