Correlates of psychotic like experiences (PLEs) during Pandemic: An online study investigating a possible link between the SARS-CoV-2 infection and PLEs among adolescents

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buir.contributor.authorToulopoulou, Timothea
dc.citation.epage43en_US
dc.citation.spage36en_US
dc.citation.volumeNumber241en_US
dc.contributor.authorYilmaz Kafali, Helin
dc.contributor.authorTuran, Serkan
dc.contributor.authorAkpınar, Serap
dc.contributor.authorMutlu, Müge
dc.contributor.authorÖzkaya Parlakay, Aslınur
dc.contributor.authorÇöp, Esra
dc.contributor.authorToulopoulou, Timothea
dc.date.accessioned2023-02-26T06:42:20Z
dc.date.available2023-02-26T06:42:20Z
dc.date.issued2022-01-05
dc.departmentDepartment of Psychologyen_US
dc.description.abstractBackground This study investigated whether SARS-CoV-2 infection, depression, anxiety, sleep problems, cigarette, alcohol, drug usage contribute to psychotic-like experiences (PLEs) among adolescents during the pandemic. We also aimed to explore whether baseline inflammatory markers or the number of SARS-CoV-2-related symptoms are associated with PLEs, and the latter is mediated by internalizing symptoms. Methods Altogether, 684 adolescents aged 12–18 (SARS-CoV-2 group n = 361, control group (CG) n = 323) were recruited. The Community Assessment of Psychic Experiences-42-Positive Dimension (CAPE-Pos), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Pittsburg Sleep Quality Index (PSQI) questionnaires were completed by all volunteers using an online survey. C-reactive Protein and hemogram values, and SARS-CoV-2-related symptoms during the acute infection period were recorded in the SARS-CoV-2 group. Group comparisons, correlations, logistic regression, and bootstrapped mediation analyses were performed. Results CAPE-Pos-Frequency/Stress scores were significantly higher, whereas GAD-7-Total and PSQI-Total scores were significantly lower in SARS-CoV-2 than CG. Among the SARS-CoV-2 group, monocyte count and the number of SARS-CoV-2-symptoms were positively correlated with CAPE-Pos-Frequency/Stress scores. Besides SARS-CoV-2, cigarette use, GAD-7, and PHQ-9 scores significantly contributed to the presence of at least one CAPE-Pos “often” or “almost always”. PHQ-9 and GAD-7 fully mediated the relationship between the number of SARS-CoV-2 symptoms and CAPE-Pos-Frequency. Conclusions This study is the first to show a possible relationship between SARS-CoV-2 infection and PLEs among adolescents. Depression, anxiety, and cigarette use also contributed to PLEs. The number of SARS-Cov-2-symptoms and PLEs association was fully mediated by internalizing symptoms, but prospective studies will need to confirm this result.en_US
dc.description.provenanceSubmitted by Cem Çağatay Akgün (cem.akgun@bilkent.edu.tr) on 2023-02-26T06:42:20Z No. of bitstreams: 1 Correlates_of_psychotic_like_experiences_(PLEs)_during_Pandemic_An_online_study_investigating_a_possible_link_between_the_SARS-CoV-2_infection_and_PLEs_among_adolescents.pdf: 728975 bytes, checksum: 3e6b7df7d7ca6b938bd3753a3f644222 (MD5)en
dc.description.provenanceMade available in DSpace on 2023-02-26T06:42:20Z (GMT). No. of bitstreams: 1 Correlates_of_psychotic_like_experiences_(PLEs)_during_Pandemic_An_online_study_investigating_a_possible_link_between_the_SARS-CoV-2_infection_and_PLEs_among_adolescents.pdf: 728975 bytes, checksum: 3e6b7df7d7ca6b938bd3753a3f644222 (MD5) Previous issue date: 2022-01-05en
dc.identifier.doi10.1016/j.schres.2021.12.049en_US
dc.identifier.issn09209964
dc.identifier.urihttp://hdl.handle.net/11693/111751
dc.language.isoEnglishen_US
dc.publisherElsevier B.V.en_US
dc.relation.isversionofhttps://dx.doi.org/10.1016/j.schres.2021.12.049en_US
dc.source.titleSchizophrenia Researchen_US
dc.subjectAdolescenceen_US
dc.subjectPsychiatryen_US
dc.subjectPsychotic like experiencesen_US
dc.subjectPandemicen_US
dc.subjectSARS-CoV-2en_US
dc.titleCorrelates of psychotic like experiences (PLEs) during Pandemic: An online study investigating a possible link between the SARS-CoV-2 infection and PLEs among adolescentsen_US
dc.typeArticleen_US

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