Chemical modulation of singlet oxygen generation rates in thermal endoperoxide decomposition & novel fluorescent sensors for hyperphosporylated tau proteins

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buir.advisorAkkaya, Engin U.
dc.contributor.authorKaya, Cansu
dc.date.accessioned2016-06-01T10:32:35Z
dc.date.available2016-06-01T10:32:35Z
dc.date.copyright2016-05
dc.date.issued2016-05
dc.date.submitted2016-05-31
dc.departmentDepartment of Chemistryen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionIncludes bibliographical references (leaves 43-47).en_US
dc.descriptionThesis (M.S.): Bilkent University, Department of Chemistry, İhsan Doğramacı Bilkent University, 2016.en_US
dc.description.abstractChemical control over singlet oxygen generation is an open to improvement because of the importance of this reactive species in biological systems. In the first project, we aimed to synthesize a silylated 1,4-dimethylnaphthalene endoperoxide derivative which is expected to release singlet oxygen on thermolysis at a relatively slow rate at room temperature. Upon the deprotection of the silyl units with fluorine ions, it is expected it to release singlet oxygen at a much higher rate, giving rise to a control over the release of the product. The absorption and the fluorescence measurement with a trap molecule which consumes the generated singlet oxygen reveals promising results for the future work for the control of singlet oxygen generation rates. In the second part of this thesis, we focused on the synthesis of a novel fluorescent sensor of a BODIPY derivative which is capable of sensing Zinc cations. The zinc complex is also expected to have a further usage for the sensing of hyperphosphorylated tau proteins, which are commonly produced in the brains of people with Alzheimer’s disease. With this, it has a potential usage in the field of early detection of Alzheimer’s disease.en_US
dc.description.degreeM.S.en_US
dc.description.statementofresponsibilityby Cansu Kaya.en_US
dc.format.extentxii, 67 leaves : illustrations, charts, graphics.en_US
dc.identifier.itemidB153356
dc.identifier.urihttp://hdl.handle.net/11693/29126
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSinglet Oxygenen_US
dc.subjectEndoperoxideen_US
dc.subjectNapthaleneen_US
dc.subjectAbsorbanceen_US
dc.subjectFluorescenceen_US
dc.subjectPhotosensitizeren_US
dc.subjectThermolysisen_US
dc.subjectChemical Modulationen_US
dc.titleChemical modulation of singlet oxygen generation rates in thermal endoperoxide decomposition & novel fluorescent sensors for hyperphosporylated tau proteinsen_US
dc.title.alternativeTermal endoperoksit dekompozisyonundakı üretim hızının kimyasal modülasyonu & hiperfosforile olmuş tau proteinlerini algılayabilen özgün floresan duyaçlarıen_US
dc.typeThesisen_US

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Dept. of Chemistry - Master's degree