Interaction of Syndecan-1 cytoplasmic domain with CASK PDZ domain

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buir.advisorSmith, Günay
dc.contributor.authorYalçin, Abdullah
dc.date.accessioned2016-01-08T20:17:38Z
dc.date.available2016-01-08T20:17:38Z
dc.date.issued2000
dc.descriptionAnkara : Department of Molecular Biology and Genetics and the Institute of Engineering and Science of Bilkent Univ., 2000.en_US
dc.descriptionThesis (Master's) -- Bilkent University, 2000.en_US
dc.descriptionIncludes bibliographical references leaves 75-79en_US
dc.description.abstractSyndecans are integral membrane proteoglycans which have important cellular functions. They are thought to function as co-receptors for various extracellular ligands like extracellular matrix molecules, cell-cell adhesion molecules, and growth fectors. It is shown that they modulate cell proliferation, cell adhesion, cell motility, and cell fate upon such interactions. Recent studies indicated that they also modulate signal transduction events by their core protein interactions. Most of these interactions are through their highly conserved cytoplasmic domains. They contain PDZ domain binding site at their carboxy terminal end, and identification of PDZ protein interactions of Syndecans may be important to explain their role in signaling. We aimed to identify a protein-protein interaction between Syndecan-1 cytoplasmic domain and PDZ domains of CASK and AF-6 proteins with yeast two-hybrid technique. We showed that there is a detectable interaction between CASK and Syndecan-1 through these domains. Our results indicated that CASK PDZ domain binds to Syndecan-1 cytoplasmic domain when expressed in yeast, and this interaction may have important functions in signaling events.en_US
dc.description.provenanceMade available in DSpace on 2016-01-08T20:17:38Z (GMT). No. of bitstreams: 1 1.pdf: 78510 bytes, checksum: d85492f20c2362aa2bcf4aad49380397 (MD5)en
dc.description.statementofresponsibilityYalçin, Abdullahen_US
dc.format.extentxiii, 79 leaves, illustrationsen_US
dc.identifier.urihttp://hdl.handle.net/11693/18246
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject.lccQP552 .Y93 2000en_US
dc.subject.lcshProteoglycans.en_US
dc.subject.lcshMembrane proteins--Physiological transport.en_US
dc.subject.lcshCellular signal transduction.en_US
dc.titleInteraction of Syndecan-1 cytoplasmic domain with CASK PDZ domainen_US
dc.typeThesisen_US
thesis.degree.disciplineMolecular Biology and Genetics
thesis.degree.grantorBilkent University
thesis.degree.levelMaster's
thesis.degree.nameMS (Master of Science)

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