Bimodal interventional instrument markers for magnetic particle imaging and magnetic resonance imaging—a proof-of-concept study

buir.contributor.orcidSarıtaş, Emine Ülkü|0000-0001-8551-1077en_US
dc.citation.epage11en_US
dc.citation.issueNumber10en_US
dc.citation.spage1en_US
dc.citation.volumeNumber12en_US
dc.contributor.authorWegner, Franz
dc.contributor.authorLüdtke-Buzug, Kerstin
dc.contributor.authorCremers, Sjef
dc.contributor.authorFriedrich, Thomas
dc.contributor.authorSieren, Malte M.
dc.contributor.authorHaegele, Julian
dc.contributor.authorKoch, Martin A.
dc.contributor.authorBorm, Paul
dc.contributor.authorBuzug, Thorsten M.
dc.contributor.authorBarkhausen, Joerg
dc.contributor.authorAhlborg, Mandy
dc.contributor.authorSarıtaş, Emine Ülkü
dc.contributor.bilkentauthorSarıtaş, Emine Ülkü
dc.date.accessioned2023-03-02T13:32:05Z
dc.date.available2023-03-02T13:32:05Z
dc.date.issued2022-05-02
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractThe purpose of this work was to develop instrument markers that are visible in both magnetic particle imaging (MPI) and magnetic resonance imaging (MRI). The instrument markers were based on two different magnetic nanoparticle types (synthesized in-house KLB and commercial Bayoxide E8706). Coatings containing one of both particle types were fabricated and measured with a magnetic particle spectrometer (MPS) to estimate their MPI performance. Coatings based on both particle types were then applied on a segment of a nonmetallic guidewire. Imaging experiments were conducted using a commercial, preclinical MPI scanner and a preclinical 1 tesla MRI system. MPI image reconstruction was performed based on system matrices measured with dried KLB and Bayoxide E8706 coatings. The bimodal markers were clearly visible in both methods. They caused circular signal voids in MRI and areas of high signal intensity in MPI. Both the signal voids as well as the areas of high signal intensity were larger than the real marker size. Images that were reconstructed with a Bayoxide E8706 system matrix did not show sufficient MPI signal. Instrument markers with bimodal visibility are essential for the perspective of monitoring cardiovascular interventions with MPI/MRI hybrid systems. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.identifier.doi10.3390/nano12101758en_US
dc.identifier.issn20794991
dc.identifier.urihttp://hdl.handle.net/11693/112028
dc.language.isoEnglishen_US
dc.publisherMDPIen_US
dc.relation.isversionofhttps://dx.doi.org/10.3390/nano12101758en_US
dc.source.titleNanomaterialsen_US
dc.subjectEndovascular Interventionsen_US
dc.subjectHybrid Imagingen_US
dc.subjectInterventional Devicesen_US
dc.subjectMagnetic Particle Imagingen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectNanoparticlesen_US
dc.titleBimodal interventional instrument markers for magnetic particle imaging and magnetic resonance imaging—a proof-of-concept studyen_US
dc.typeArticleen_US
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