Alternatively spliced Robo2 isoforms in zebrafish and rat

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dc.citation.epage563en_US
dc.citation.issueNumber9en_US
dc.citation.spage555en_US
dc.citation.volumeNumber216en_US
dc.contributor.authorDalkic, E.en_US
dc.contributor.authorKuscu, C.en_US
dc.contributor.authorSucularli, C.en_US
dc.contributor.authorAydin, I. T.en_US
dc.contributor.authorAkcali, K. C.en_US
dc.contributor.authorKonu, O.en_US
dc.date.accessioned2016-02-08T10:18:15Z
dc.date.available2016-02-08T10:18:15Z
dc.date.issued2006en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractRobo2, a member of the robo gene family, functions as a repulsive axon guidance receptor as well as a regulator of cell migration and tissue morphogenesis in different taxa. In this study, a novel isoform of the zebrafish robo2 (robo2_tv2), which included an otherwise alternatively spliced exon (CAE), has been characterized. Robo2_tv2 is expressed differentially in most non-neuronal tissues of adult zebrafish whereas robo2_tv1 expression to a great extent is restricted to the brain and eye. In zebrafish, robo2_tv2 exhibits a very-low-level basal expression starting from 1 day post fertilization until the mid-larval stages, at which time its expression increases dramatically and could be detected throughout adulthood. Our findings demonstrate that the amino acid sequence coded by CAE of the robo2 gene is highly conserved between zebrafish and mammals, and also contains conserved motifs shared with robo1 and robo4 but not with robo3. Furthermore, we provide an account of differential transcription of the CAE homolog in various tissues of the adult rat. These results suggest that the alternatively spliced robo2 isoforms may exhibit tissue specificity. © Springer-Verlag 2006.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:18:15Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2006en
dc.identifier.doi10.1007/s00427-006-0070-yen_US
dc.identifier.issn0949-944X
dc.identifier.urihttp://hdl.handle.net/11693/23726
dc.language.isoEnglishen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s00427-006-0070-yen_US
dc.source.titleDevelopment Genes and Evolutionen_US
dc.subjectAlternative splicingen_US
dc.subjectDanio rerioen_US
dc.subjectDifferential expressionen_US
dc.subjectRattus norvegicusen_US
dc.subjectRobo2en_US
dc.subjectIsoproteinen_US
dc.subjectMembrane receptoren_US
dc.subjectProtein ROBO1en_US
dc.subjectProtein Robo2en_US
dc.subjectProtein ROBO3en_US
dc.subjectProtein robo4en_US
dc.subjectRoundabout receptoren_US
dc.subjectUnclassified drugen_US
dc.titleAlternatively spliced Robo2 isoforms in zebrafish and raten_US
dc.typeArticleen_US

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