Simultaneous radiofrequency (RF) heating and magnetic resonance (MR) thermal mapping using an intravascular MR imaging/RF heating system

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buir.contributor.authorAtalar, Ergin
dc.citation.epage230en_US
dc.citation.issueNumber1en_US
dc.citation.spage226en_US
dc.citation.volumeNumber54en_US
dc.contributor.authorQiu, B.en_US
dc.contributor.authorEl-Sharkawy, A.-M.en_US
dc.contributor.authorPaliwal, V.en_US
dc.contributor.authorKarmarkar, P.en_US
dc.contributor.authorGao, F.en_US
dc.contributor.authorAtalar, Erginen_US
dc.contributor.authorYang, X.en_US
dc.date.accessioned2016-02-08T10:23:03Z
dc.date.available2016-02-08T10:23:03Z
dc.date.issued2005-06en_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.description.abstractPrevious studies have confirmed the possibility of using an intravascular MR imaging guidewire (MRIG) as a heating source to enhance vascular gene transfection/expression. This motivated us to develop a new intravascular system that can perform MR imaging, radiofrequncy (RF) heating, and MR temperature monitoring simultaneously in an MR scanner. To validate this concept, a series of mathematical simulations of RF power loss along a 0.032-inch MRIG and RF energy spatial distribution were performed to determine the optimum RF heating frequency. Then, an RF generator/amplifier and a filter box were built. The possibility for simultaneous RF heating and MR thermal mapping of the system was confirmed in vitro using a phantom, and the obtained thermal mapping profile was compared with the simulated RF power distribution. Subsequently, the feasibility of simultaneous RF heating and temperature monitoring was successfully validated in vivo in the aorta of living rabbits. This MR imaging/RF heating system offers a potential tool for intravascular MR-mediated, RF-enhanced vascular gene therapy.en_US
dc.identifier.doi10.1002/mrm.20521en_US
dc.identifier.eissn1522-2594
dc.identifier.issn0740-3194
dc.identifier.urihttp://hdl.handle.net/11693/24030
dc.language.isoEnglishen_US
dc.publisherJohn Wiley & Sonsen_US
dc.relation.isversionofhttps://doi.org/10.1002/mrm.20521en_US
dc.source.titleMagnetic Resonance in Medicineen_US
dc.subjectGene therapyen_US
dc.subjectIntravascular MRIen_US
dc.subjectMR imaging guide-wireen_US
dc.subjectMR thermal mappingen_US
dc.subjectRadiofrequencyen_US
dc.subjectThermographyen_US
dc.titleSimultaneous radiofrequency (RF) heating and magnetic resonance (MR) thermal mapping using an intravascular MR imaging/RF heating systemen_US
dc.typeArticleen_US

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