NAPO as a novel marker for apoptosis

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dc.citation.epage724en_US
dc.citation.issueNumber5en_US
dc.citation.spage719en_US
dc.citation.volumeNumber155en_US
dc.contributor.authorSayan, B. S.en_US
dc.contributor.authorInce, G.en_US
dc.contributor.authorSayan, A. E.en_US
dc.contributor.authorOzturk, M.en_US
dc.date.accessioned2016-02-08T10:34:20Z
dc.date.available2016-02-08T10:34:20Z
dc.date.issued2001en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractApoptosis or programmed cell death plays a pivotal role in embryonic development and maintenance of homeostasis. It is also involved in the etiology of pathophysiological conditions such as cancer, neurodegenerative, autoimmune, infectious, and heart diseases. Consequently, the study of apoptosis is now at center of both basic and clinical research applications. Therefore, sensitive and simple apoptosis detection techniques are required. Here we describe a monoclonal antibody-defined novel antigen, namely NAPO (negative in apoptosis), which is specifically lost during apoptosis. The anti-NAPO antibody recognizes two nuclear polypeptides of 60 and 70 kD. The antigen is maintained in quiescent and senescent cells, as well as in different phases of the cell cycle, including mitosis. Thus, immunodetection of NAPO antigen provides a specific, sensitive, and easy method for differential identification of apoptotic and nonapoptotic cells.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:34:20Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2001en
dc.identifier.doi10.1083/jcb.200106044en_US
dc.identifier.issn0021-9525
dc.identifier.urihttp://hdl.handle.net/11693/24785
dc.language.isoEnglishen_US
dc.publisherThe Rockefeller University Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1083/jcb.200106044en_US
dc.source.titleJournal of Cell Biologyen_US
dc.subjectApoptosisen_US
dc.subjectApoptotic cell deathen_US
dc.subjectApoptotic markeren_US
dc.subjectQuiescenceen_US
dc.subjectSenescenceen_US
dc.subjectBeta galactosidaseen_US
dc.subjectCell nucleus antigenen_US
dc.subjectMonoclonal antibodyen_US
dc.subjectNegative in apoptosis antigenen_US
dc.subjectPolypeptideen_US
dc.subjectUnclassified drugen_US
dc.subjectAnimal cellen_US
dc.subjectAntigen expressionen_US
dc.subjectAntigen specificityen_US
dc.subjectCell Agingen_US
dc.subjectCell Cycleen_US
dc.subjectCell Lineen_US
dc.subjectCell Nucleusen_US
dc.titleNAPO as a novel marker for apoptosisen_US
dc.typeArticleen_US

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