The effects of respiratory muscle training on resting-state brain activity and thoracic mobility in healthy subjects: A randomized controlled trial
buir.contributor.author | Karli-Oguz, Kader | |
buir.contributor.author | Dasgin, Hacer | |
dc.citation.epage | 417 | en_US |
dc.citation.issueNumber | 2 | en_US |
dc.citation.spage | 403 | en_US |
dc.citation.volumeNumber | 57 | en_US |
dc.contributor.author | Karli-Oguz, Kader | |
dc.contributor.author | Dasgin, Hacer | |
dc.contributor.author | Vardar-Yagli, N. | |
dc.contributor.author | Saglam, M. | |
dc.date.accessioned | 2023-02-16T12:11:17Z | |
dc.date.available | 2023-02-16T12:11:17Z | |
dc.date.issued | 2022-06-28 | |
dc.department | Department of Physics | en_US |
dc.department | National Magnetic Resonance Research Center (UMRAM) | en_US |
dc.description.abstract | Background: Although inspiratory muscle training (IMT) is an effective intervention for improving breath perception, brain mechanisms have not been studied yet. Purpose: To examine the effects of IMT on insula and default mode network (DMN) using resting-state functional MRI (RS-fMRI). Study Type: Prospective. Population: A total of 26 healthy participants were randomly assigned to two groups as IMT group (n = 14) and sham IMT groups (n = 12). Field Strength/Sequence: A 3-T, three-dimensional T2* gradient-echo echo planar imaging sequence for RS-fMRI was obtained. Assessment: The intervention group received IMT at 60% and sham group received at 15% of maximal inspiratory pressure (MIP) for 8 weeks. Pulmonary and respiratory muscle function, and breathing patterns were measured. Groups underwent RS-fMRI before and after the treatment. Statistical Tests: Statistical tests were two-tailed P < 0.05 was considered statistically significant. Student’s test was used to compare the groups. One-sample t-test for each group was used to reveal pattern of functional connectivity. A statistical threshold of P < 0.001 uncorrected value was set at voxel level. We used False discovery rate (FDR)-corrected P < 0.05 cluster level. Results: The IMT group showed more prominent alterations in insula and DMN connectivity than sham group. The MIP was significantly different after IMT. Respiratory rate (P = 0.344), inspiratory time (P = 0.222), expiratory time (P = 1.000), and inspiratory time/total breath time (P = 0.572) of respiratory patterns showed no significant change after IMT. All DMN components showed decreased, while insula showed increased activation significantly. Data Conclusion: Differences in brain activity and connectivity may reflect improved ventilatory perception with IMT with a possible role in regulating breathing pattern by processing interoceptive signals. Evidence Level: 2 Technical Efficacy: Stage 4 | en_US |
dc.description.provenance | Submitted by İrem Aro (iremaro18@gmail.com) on 2023-02-16T12:11:17Z No. of bitstreams: 2 The_effects_of_respiratory_muscle_training_on_resting-state_brain_activity_and_thoracic_mobility_in_healthy_subjects_A_randomized_controlled_trial.pdf: 9916127 bytes, checksum: 6f1e0dc4f34e9964b8a37b05d5466a42 (MD5) The_effects_of_respiratory_muscle_training_on_resting-state_brain_activity_and_thoracic_mobility_in_healthy_subjects_A_randomized_controlled_trial.pdf: 9918414 bytes, checksum: fe25ceed34e948562fde1106078a4f9b (MD5) | en |
dc.description.provenance | Made available in DSpace on 2023-02-16T12:11:17Z (GMT). No. of bitstreams: 2 The_effects_of_respiratory_muscle_training_on_resting-state_brain_activity_and_thoracic_mobility_in_healthy_subjects_A_randomized_controlled_trial.pdf: 9916127 bytes, checksum: 6f1e0dc4f34e9964b8a37b05d5466a42 (MD5) The_effects_of_respiratory_muscle_training_on_resting-state_brain_activity_and_thoracic_mobility_in_healthy_subjects_A_randomized_controlled_trial.pdf: 9918414 bytes, checksum: fe25ceed34e948562fde1106078a4f9b (MD5) Previous issue date: 2022-06-28 | en |
dc.identifier.doi | 10.1002/jmri.28322 | en_US |
dc.identifier.eissn | 1522-2586 | |
dc.identifier.issn | 1053-1807 | |
dc.identifier.uri | http://hdl.handle.net/11693/111457 | |
dc.language.iso | English | en_US |
dc.relation.isversionof | https://doi.org/10.1002/jmri.28322 | en_US |
dc.source.title | Journal of Magnetic Resonance Imaging | en_US |
dc.title | The effects of respiratory muscle training on resting-state brain activity and thoracic mobility in healthy subjects: A randomized controlled trial | en_US |
dc.type | Article | en_US |
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