p53 codon 72 polymorphism in bladder cancer-No evidence of association with increased risk or invasiveness

dc.citation.epage395en_US
dc.citation.issueNumber6en_US
dc.citation.spage393en_US
dc.citation.volumeNumber29en_US
dc.contributor.authorTörüner, G. A.en_US
dc.contributor.authorUçar, A.en_US
dc.contributor.authorTez, M.en_US
dc.contributor.authorÇetinkaya, M.en_US
dc.contributor.authorÖzen, H.en_US
dc.contributor.authorÖzçelik, T.en_US
dc.date.accessioned2016-02-08T10:33:59Z
dc.date.available2016-02-08T10:33:59Z
dc.date.issued2001en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractWe studied the effect of the p53 gene Arg72Pro polymorphism on bladder cancer susceptibility in a case control study of 121 bladder cancer patients and 114 age-sex matched controls to determine whether this polymorphism is a biomarker for the risk and how aggressive the disease is. Genomic DNA was obtained from venous blood samples for genotype determination by PCR and restriction digestion. The genotype frequencies in the patient group were Arg/Arg: 0.3553, Arg/Pro: 0.4711, Pro/Pro: 0.1736, and in the control group Arg/Arg: 0.3684, Arg/Pro: 0.4825, Pro/Pro: 0.1491. The distribution of genotypes between the two groups was not statistically different (χ2 = 0.260, df: 2, P = 0.878). The patient group was subdivided into two groups as superficial bladder cancer (n = 88) and invasive bladder cancer (n = 33), according to the presence of muscle invasion. The distribution of genotypes in the superficial group was Arg/Arg: 0.3409, Arg/Pro: 0.5114, Pro/Pro: 0.1477 and in the invasive group Arg/Arg: 0.3940, Arg/Pro: 0.3636, Pro/Pro: 0.2424. No association was observed with the invasiveness of the tumor (χ2 = 2.542, df: 2, P = 0.281). Stratification of the data by tobacco exposure did not result in a significant difference in genotype frequencies. These data do not support an association between the p53 Arg72Pro polymorphism and bladder cancer.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:33:59Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2001en
dc.identifier.doi10.1007/s002400100218en_US
dc.identifier.issn0300-5623
dc.identifier.urihttp://hdl.handle.net/11693/24759
dc.language.isoEnglishen_US
dc.publisherSpringeren_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s002400100218en_US
dc.source.titleUrological Researchen_US
dc.subjectBladder canceren_US
dc.subjectGenetic susceptibilityen_US
dc.subjectTP53 polymorphismen_US
dc.subjectBiological markeren_US
dc.subjectProtein p53en_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectBladder carcinomaen_US
dc.subjectCancer invasionen_US
dc.subjectCancer risken_US
dc.subjectCancer susceptibilityen_US
dc.subjectCigarette smokingen_US
dc.subjectControlled studyen_US
dc.subjectDisease activityen_US
dc.subjectDNA polymorphismen_US
dc.subjectFemaleen_US
dc.subjectGene frequencyen_US
dc.subjectGenetic predispositionen_US
dc.subjectGenotypeen_US
dc.subjectHistopathologyen_US
dc.subjectHumanen_US
dc.subjectHuman tissueen_US
dc.subjectMajor clinical studyen_US
dc.subjectMaleen_US
dc.subjectPolymerase chain reactionen_US
dc.subjectPriority journalen_US
dc.subjectRisk assessmenten_US
dc.subjectAged, 80 and overen_US
dc.subjectFemaleen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectGenotypeen_US
dc.subjectHumansen_US
dc.subjectMiddle Ageden_US
dc.subjectNeoplasm invasivenessen_US
dc.subjectPolymorphism, single nucleotideen_US
dc.subjectRisk factorsen_US
dc.subjectTumor Suppressor Protein p53en_US
dc.subjectUrinary Bladder Neoplasmsen_US
dc.titlep53 codon 72 polymorphism in bladder cancer-No evidence of association with increased risk or invasivenessen_US
dc.typeArticleen_US

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