Model based analysis of the variation in Korotkoff sound onset time during exercise

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dc.citation.epage445en_US
dc.citation.issueNumber3en_US
dc.citation.spage433en_US
dc.citation.volumeNumber22en_US
dc.contributor.authorTürkmen, A.en_US
dc.contributor.authorIder, Y. Z.en_US
dc.date.accessioned2016-02-08T10:34:40Z
dc.date.available2016-02-08T10:34:40Z
dc.date.issued2001en_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.description.abstractIn this study, a minimal mathematical model of the cardiovascular system is used to study the effects of changes in arterial compliance and cardiac contractility on the onset time of Korotkoff sounds during an auscultatory procedure. The model provides blood pressure waveforms in the ventricle, the aorta and the brachial artery. From these waveforms, pre-ejection time, pulse propagation time and rise time of the blood pressure at the brachial artery can be computed. The time delay between onset time of ECG Q wave and onset time of Korotkoff sound is the sum of these three times. Rise time is zero and the time delay is minimal when the cuff pressure is slightly above the diastolic pressure. This minimum time delay is represented by QKD. Simulation results suggest that during the Bruce exercise protocol QKD decreases to one-third of its pre-exercise value if the cardiac contractility increases threefold. The effect of arterial compliance is not as significant as that of the cardiac contractility. From data recorded during an exercise test, it is observed that QKD decreases considerably as the test load is increased. We show in this study that the amount of decrease in QKD can be used as an index of the amount of increase in cardiac contractility during an exercise ECG test. Use of signal averaging for reducing the effect of motion artifacts during an exercise test is also shown to be very instrumental for making accurate QKD measurements.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:34:40Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2001en
dc.identifier.doi10.1088/0967-3334/22/3/302en_US
dc.identifier.issn0967-3334
dc.identifier.urihttp://hdl.handle.net/11693/24809
dc.language.isoEnglishen_US
dc.publisherInstitute of Physics Publishingen_US
dc.relation.isversionofhttp://dx.doi.org/10.1088/0967-3334/22/3/302en_US
dc.source.titlePhysiological Measurementen_US
dc.subjectArterial complianceen_US
dc.subjectCardiac contractilityen_US
dc.subjectCardiovascular system modellingen_US
dc.subjectDiastolic pressureen_US
dc.subjectExercise testen_US
dc.subjectKorotkoff sounden_US
dc.subjectPre-ejection timeen_US
dc.subjectPulse pressure propagationen_US
dc.subjectQKDen_US
dc.subjectSystolic pressureen_US
dc.subjectAortaen_US
dc.subjectArtery complianceen_US
dc.subjectBlood pressure measurementen_US
dc.subjectBrachial arteryen_US
dc.subjectCardiovascular systemen_US
dc.subjectComputer simulationen_US
dc.subjectElectrocardiogramen_US
dc.subjectHeart auscultationen_US
dc.subjectHeart muscle contractilityen_US
dc.subjectHeart ventricleen_US
dc.subjectHeart ventricle ejection timeen_US
dc.subjectKorotkow sounden_US
dc.subjectMathematical modelen_US
dc.subjectQ waveen_US
dc.subjectQKD intervalen_US
dc.subjectSignal averaged electrocardiographyen_US
dc.subjectAortaen_US
dc.subjectAuscultationen_US
dc.subjectBlood Pressureen_US
dc.subjectBrachial Arteryen_US
dc.subjectComplianceen_US
dc.subjectElectrocardiographyen_US
dc.subjectModels, Cardiovascularen_US
dc.titleModel based analysis of the variation in Korotkoff sound onset time during exerciseen_US
dc.typeArticleen_US

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