Local object patterns for tissue image representation and cancer classification

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buir.advisorDemir, Çiğdem Gündüz
dc.contributor.authorOlgun, Gülden
dc.date.accessioned2016-01-08T20:06:10Z
dc.date.available2016-01-08T20:06:10Z
dc.date.issued2013
dc.descriptionAnkara : The Department of Computer Engineering and the Graduate School of Engineering and Science of Bilkent Univ., 2013.en_US
dc.descriptionThesis (Master's) -- Bilkent University, 2013.en_US
dc.descriptionIncludes bibliographical refences.en_US
dc.description.abstractHistopathological examination of a tissue is the routine practice for diagnosis and grading of cancer. However, this examination is subjective since it requires visual interpretation of a pathologist, which mainly depends on his/her experience and expertise. In order to minimize the subjectivity level, it has been proposed to use automated cancer diagnosis and grading systems that represent a tissue image with quantitative features and use these features for classifying and grading the tissue. In this thesis, we present a new approach for effective representation and classification of histopathological tissue images. In this approach, we propose to decompose a tissue image into its histological components and introduce a set of new texture descriptors, which we call local object patterns, on these components to model their composition within a tissue. We define these descriptors using the idea of local binary patterns. However, we define our local object pattern descriptors at the component-level to quantify a component, as opposed to pixel-level local binary patterns, which quantify a pixel by constructing a binary string based on relative intensities of its neighbors. To this end, we specify neighborhoods with different locality ranges and encode spatial arrangements of the components within the specified local neighborhoods by generating strings. We then extract our texture descriptors from these strings to characterize histological components and construct the bag-of-words representation of an image from the characterized components. In this thesis, we use two approaches for the selection of the components: The first approach uses all components to construct a bag-ofwords representation whereas the second one uses graph walking to select multiple subsets of the components and constructs multiple bag-of-words representations from these subsets. Working with microscopic images of histopathological colon tissues, our experiments show that the proposed component-level texture descriptors lead to higher classification accuracies than the previous textural approaches.en_US
dc.description.provenanceMade available in DSpace on 2016-01-08T20:06:10Z (GMT). No. of bitstreams: 1 0007044.pdf: 1404403 bytes, checksum: 059515afe94354ec13781828adf7f270 (MD5)en
dc.description.statementofresponsibilityOlgun, Güldenen_US
dc.format.extentxiii, 50 leaves, graphicsen_US
dc.identifier.itemidB123500
dc.identifier.urihttp://hdl.handle.net/11693/17071
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDigital pathologyen_US
dc.subjectTissue image representationen_US
dc.subjectClassification,en_US
dc.subjectTextureen_US
dc.subjectLocal patternsen_US
dc.subjectGraph walksen_US
dc.subjectColon canceren_US
dc.subject.lccWB141 .O43 2013en_US
dc.subject.lcshDiagnostic imaging--Digital techniques.en_US
dc.subject.lcshImage processing--Digital techniques.en_US
dc.subject.lcshImage systems in medicine.en_US
dc.subject.lcshComputer graphics.en_US
dc.subject.lcshMedical image analysis.en_US
dc.subject.lcshCancer--Diagnosis--Data processing.en_US
dc.subject.lcshColon (Anatomy)--Cancer--Diagnosis.en_US
dc.titleLocal object patterns for tissue image representation and cancer classificationen_US
dc.typeThesisen_US
thesis.degree.disciplineComputer Engineering
thesis.degree.grantorBilkent University
thesis.degree.levelMaster's
thesis.degree.nameMS (Master of Science)

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