Visfatin concentration is decreased in women with gestational diabetes mellitus in the third trimester

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dc.citation.epage613en_US
dc.citation.issueNumber7en_US
dc.citation.spage610en_US
dc.citation.volumeNumber31en_US
dc.contributor.authorAkturk, M.en_US
dc.contributor.authorAltinova, A.E.en_US
dc.contributor.authorMert I.en_US
dc.contributor.authorBuyukkagnici, U.en_US
dc.contributor.authorSargin, A.en_US
dc.contributor.authorArslan, M.en_US
dc.contributor.authorDanisman, N.en_US
dc.date.accessioned2016-02-08T10:08:27Z
dc.date.available2016-02-08T10:08:27Z
dc.date.issued2008en_US
dc.departmentDepartment of Chemistryen_US
dc.description.abstractOur aim is to investigate visfatin concentration and its relationship to glycated hemoglobin (HbA1c), insulin resistance, lipid parameters, and neonatal birth weight in women with gestational diabetes mellitus (GDM). In our study group, there were 47 women with GDM and 31 women with normal glucose tolerance (NGT) between 33-39 weeks of gestation. Plasma visfatin levels were significantly decreased in pregnant women with GDM compared to those with NGT (p=0.001). Homeostasis model assessment-insulin resistance (HOMA-IR) levels were higher in the GDM group than in the NGT group (p=0.006). In all subjects, plasma visfatin levels were negatively correlated with HOMA-IR, post-prandial blood glucose, triglycerides, and VLDL cholesterol (p<0.05). We did not observe any statistically significant correlation between the plasma visfatin levels and the selected parameters in the GDM group, but in the NGT group plasma visfatin levels were negatively correlated with HOMA-IR (r=-0.36, p=0.04). There was no correlation between visfatin concentrations and fetal birth weight in either group (p>0.05). By regression analysis, having GDM was found to be the only significant determinant (t=3.5, p=0.001) of visfatin concentration (R=0.39, r2=0.15). We conclude that women with GDM have significantly decreased visfatin concentrations in the third trimester. Future studies are required to establish the exact role of visfatin in the pathogenesis of GDM. ©2008, Editrice Kurtis.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:08:27Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2008en
dc.identifier.issn0391-4097
dc.identifier.urihttp://hdl.handle.net/11693/23065
dc.language.isoEnglishen_US
dc.source.titleJournal of Endocrinological Investigationen_US
dc.subjectBirth weighten_US
dc.subjectGestational diabetes mellitusen_US
dc.subjectHOMA-IRen_US
dc.subjectThird trimesteren_US
dc.subjectVisfatinen_US
dc.subjectglucoseen_US
dc.subjecthemoglobin A1cen_US
dc.subjecthigh density lipoprotein cholesterolen_US
dc.subjectlow density lipoprotein cholesterolen_US
dc.subjecttriacylglycerolen_US
dc.subjectvery low density lipoprotein cholesterolen_US
dc.subjectvisfatinen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectbirth weighten_US
dc.subjectcholesterol blood levelen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectfemaleen_US
dc.subjectglucose blood levelen_US
dc.subjectglucose toleranceen_US
dc.subjecthemoglobin determinationen_US
dc.subjecthumanen_US
dc.subjectinsulin resistanceen_US
dc.subjectinsulin treatmenten_US
dc.subjectmaternal blooden_US
dc.subjectnormal glucose toleranceen_US
dc.subjectnutritional supporten_US
dc.subjectpregnancy diabetes mellitusen_US
dc.subjectprotein blood levelen_US
dc.subjectthird trimester pregnancyen_US
dc.subjecttriacylglycerol blood levelen_US
dc.subjectAdulten_US
dc.subjectDiabetes, Gestationalen_US
dc.subjectFemaleen_US
dc.subjectGestational Ageen_US
dc.subjectHemoglobin A, Glycosylateden_US
dc.subjectHumansen_US
dc.subjectNicotinamide Phosphoribosyltransferaseen_US
dc.subjectPregnancyen_US
dc.subjectPregnancy Trimester, Thirden_US
dc.subjectStatistics as Topicen_US
dc.titleVisfatin concentration is decreased in women with gestational diabetes mellitus in the third trimesteren_US
dc.typeArticleen_US

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