Ant i-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behcet's disease

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dc.citation.epage97en_US
dc.citation.issueNumber1-2en_US
dc.citation.spage91en_US
dc.citation.volumeNumber239en_US
dc.contributor.authorVural, B.en_US
dc.contributor.authorUğurel, E.en_US
dc.contributor.authorTüzün, E.en_US
dc.contributor.authorKürtüncü, M.en_US
dc.contributor.authorZuliani, L.en_US
dc.contributor.authorÇavus, F.en_US
dc.contributor.authorİçoz, S.en_US
dc.contributor.authorErdağ, E.en_US
dc.contributor.authorGül, A.en_US
dc.contributor.authorGüre, A. O.en_US
dc.contributor.authorVincent, A.en_US
dc.contributor.authorÖzbek, U.en_US
dc.contributor.authorEraksoy, M.en_US
dc.contributor.authorDemir, G. A.en_US
dc.date.accessioned2015-07-28T12:00:17Z
dc.date.available2015-07-28T12:00:17Z
dc.date.issued2011-10-28en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractNo disease-specific neuronal antibodies have so far been defined in neuro-Behçet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD. © 2011 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.jneuroim.2011.08.008en_US
dc.identifier.issn0165-5728
dc.identifier.urihttp://hdl.handle.net/11693/12155
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.jneuroim.2011.08.008en_US
dc.source.titleJournal of Neuroimmunologyen_US
dc.subjectBehçet's diseaseen_US
dc.subjectNeuro-Behçet's diseaseen_US
dc.subjectAnti-neuronal antibodyen_US
dc.subjectStress-induced-phosphoprotein 1en_US
dc.subjectAntibodyen_US
dc.subjectAutoimmunityen_US
dc.titleAnt i-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behcet's diseaseen_US
dc.typeArticleen_US

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