Cytotoxic activities of some novel benzhydrylpiperazine derivatives
| dc.citation.epage | 128 | en_US |
| dc.citation.issueNumber | 3 | en_US |
| dc.citation.spage | 121 | en_US |
| dc.citation.volumeNumber | 63 | en_US |
| dc.contributor.author | Gurdal, E. E. | en_US |
| dc.contributor.author | Yarim, M. | en_US |
| dc.contributor.author | Durmaz, I. | en_US |
| dc.contributor.author | Cetin Atalay, R. | en_US |
| dc.date.accessioned | 2016-02-08T09:41:55Z | |
| dc.date.available | 2016-02-08T09:41:55Z | |
| dc.date.issued | 2013 | en_US |
| dc.department | Department of Molecular Biology and Genetics | en_US |
| dc.description.abstract | This study presents the synthesis of nineteen 1-(substitutedbenzoyl)-4- benzhydrylpiperazine and 1-[(substitutedphenyl)sulfonyl]-4-benzhydrylpiperazine derivatives. In vitro cytotoxic activities of the compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Among the test compounds, benzamide derivatives had high cytotoxic activity whereas sulfonamide derivatives showed variable 50% growth inhibition (GI50). © Georg Thieme Verlag KG Stuttgart · New York. | en_US |
| dc.description.provenance | Made available in DSpace on 2016-02-08T09:41:55Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2013 | en |
| dc.identifier.doi | 10.1055/s-0032-1333275 | en_US |
| dc.identifier.issn | 2194-9379 | |
| dc.identifier.uri | http://hdl.handle.net/11693/21150 | |
| dc.language.iso | English | en_US |
| dc.publisher | Georg Thieme Verlag | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1055/s-0032-1333275 | en_US |
| dc.source.title | Drug Research | en_US |
| dc.subject | Benzhydrylpiperazine | en_US |
| dc.subject | Benzoyl chloride | en_US |
| dc.subject | Cytotoxicity | en_US |
| dc.subject | Sulfonyl chloride | en_US |
| dc.subject | Sulphorhodamine B | en_US |
| dc.subject | antineoplastic agent | en_US |
| dc.title | Cytotoxic activities of some novel benzhydrylpiperazine derivatives | en_US |
| dc.type | Article | en_US |
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