Cytotoxic activities of some novel benzhydrylpiperazine derivatives

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dc.citation.epage128en_US
dc.citation.issueNumber3en_US
dc.citation.spage121en_US
dc.citation.volumeNumber63en_US
dc.contributor.authorGurdal, E. E.en_US
dc.contributor.authorYarim, M.en_US
dc.contributor.authorDurmaz, I.en_US
dc.contributor.authorCetin Atalay, R.en_US
dc.date.accessioned2016-02-08T09:41:55Z
dc.date.available2016-02-08T09:41:55Z
dc.date.issued2013en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractThis study presents the synthesis of nineteen 1-(substitutedbenzoyl)-4- benzhydrylpiperazine and 1-[(substitutedphenyl)sulfonyl]-4-benzhydrylpiperazine derivatives. In vitro cytotoxic activities of the compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Among the test compounds, benzamide derivatives had high cytotoxic activity whereas sulfonamide derivatives showed variable 50% growth inhibition (GI50). © Georg Thieme Verlag KG Stuttgart · New York.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:41:55Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2013en
dc.identifier.doi10.1055/s-0032-1333275en_US
dc.identifier.issn2194-9379
dc.identifier.urihttp://hdl.handle.net/11693/21150
dc.language.isoEnglishen_US
dc.publisherGeorg Thieme Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1055/s-0032-1333275en_US
dc.source.titleDrug Researchen_US
dc.subjectBenzhydrylpiperazineen_US
dc.subjectBenzoyl chlorideen_US
dc.subjectCytotoxicityen_US
dc.subjectSulfonyl chlorideen_US
dc.subjectSulphorhodamine Ben_US
dc.subjectantineoplastic agenten_US
dc.titleCytotoxic activities of some novel benzhydrylpiperazine derivativesen_US
dc.typeArticleen_US

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