Mechanistic pathways of malignancy in breast cancer stem cells

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buir.contributor.authorGüre, Ali Osmay
dc.citation.epage15en_US
dc.citation.spage1en_US
dc.citation.volumeNumber10en_US
dc.contributor.authorYousefnia, S.
dc.contributor.authorForootan, F. S.
dc.contributor.authorForootan, S. S.
dc.contributor.authorEsfahani, M. H. N.
dc.contributor.authorGüre, Ali Osmay
dc.date.accessioned2021-02-10T13:30:02Z
dc.date.available2021-02-10T13:30:02Z
dc.date.issued2020-04-30
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractBreast cancer stem cells (BCSCs) are the minor population of breast cancer (BC) cells that exhibit several phenotypes such as migration, invasion, self-renewal, and chemotherapy as well as radiotherapy resistance. Recently, BCSCs have been more considerable due to their capacity for recurrence of tumors after treatment. Recognition of signaling pathways and molecular mechanisms involved in stemness phenotypes of BCSCs could be effective for discovering novel treatment strategies to target BCSCs. This review introduces BCSC markers, their roles in stemness phenotypes, and the dysregulated signaling pathways involved in BCSCs such as mitogen-activated protein (MAP) kinase, PI3K/Akt/nuclear factor kappa B (NFκB), TGF-β, hedgehog (Hh), Notch, Wnt/β-catenin, and Hippo pathway. In addition, this review presents recently discovered molecular mechanisms implicated in chemotherapy and radiotherapy resistance, migration, metastasis, and angiogenesis of BCSCs. Finally, we reviewed the role of microRNAs (miRNAs) in BCSCs as well as several other therapeutic strategies such as herbal medicine, biological agents, anti-inflammatory drugs, monoclonal antibodies, nanoparticles, and microRNAs, which have been more considerable in the last decades.en_US
dc.identifier.doi10.3389/fonc.2020.00452en_US
dc.identifier.issn2234-943X
dc.identifier.urihttp://hdl.handle.net/11693/55051
dc.language.isoEnglishen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.isversionofhttps://doi.org/10.3389/fonc.2020.00452en_US
dc.source.titleFrontiers in Oncologyen_US
dc.subjectAngiogenesisen_US
dc.subjectBreast cancer stem cellen_US
dc.subjectChemotherapy and radiotherapy resistanceen_US
dc.subjectInvasionen_US
dc.subjectMetastasisen_US
dc.titleMechanistic pathways of malignancy in breast cancer stem cellsen_US
dc.typeReviewen_US

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