Eliciting immune response by using nanostructures

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buir.advisorTekinay, Ayşe Begüm
dc.contributor.authorGünay, Gökhan
dc.date.accessioned2017-07-24T14:04:52Z
dc.date.available2017-07-24T14:04:52Z
dc.date.copyright2017-06
dc.date.issued2017-06
dc.date.submitted2017-07-20
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (M.S.): Bilkent University, Department of Neuroscience, İhsan Doğramacı Bilkent University, 2017.en_US
dc.descriptionIncludes bibliographical references (leaves 76-91).en_US
dc.description.abstractThe ability of dendritic cells to coordinate innate and adaptive immune responses makes them essential targets for vaccination strategies. Presentation of specific antigens by dendritic cells is required for the activation of the immune system against many pathogens and cancer, and nanoscale materials can be functionalized for active targeting of dendritic cells. In this work, we integrated an immunogenic, carbohydrate melanoma-associated antigen-mimetic GM3-lactone molecule into mannosylated peptide amphiphile nanofibers to target dendritic cells through DC-SIGN receptor. Based on morphological and functional analyses, when dendritic cells were treated with peptide nanofiber carriers, they showed significant increase in antigen internalization and a corresponding increase in the surface expression of the activation and maturation markers CD86, CD83 and HLA-DR, in addition to exhibiting a general morphology consistent with dendritic cell maturation. These results indicate that mannosylated peptide amphiphile nanofiber carriers are promising candidates to target dendritic cells for antigen delivery. Overall these structures are proven to be effective in terms of dendritic cell activation and maturation and hold high potential to be used with a variety of antigens for different immunotherapy purposes.en_US
dc.description.provenanceSubmitted by Betül Özen (ozen@bilkent.edu.tr) on 2017-07-24T14:04:52Z No. of bitstreams: 1 Gökhan Thesis_son__.pdf: 4769342 bytes, checksum: f773b478633c597491c68aa58ffc7068 (MD5)en
dc.description.provenanceMade available in DSpace on 2017-07-24T14:04:52Z (GMT). No. of bitstreams: 1 Gökhan Thesis_son__.pdf: 4769342 bytes, checksum: f773b478633c597491c68aa58ffc7068 (MD5) Previous issue date: 2017-07en
dc.description.statementofresponsibilityby Gökhan Günay.en_US
dc.embargo.release2019-07-15
dc.format.extentxv, 91 leaves : charts (some color) ; 29 cmen_US
dc.identifier.itemidB156010
dc.identifier.urihttp://hdl.handle.net/11693/33506
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCancer immunotherapyen_US
dc.subjectCancer antigensen_US
dc.subjectDendritic cellsen_US
dc.subjectCarbohydrate melanoma associated antigenen_US
dc.subjectPeptide amphiphilesen_US
dc.titleEliciting immune response by using nanostructuresen_US
dc.title.alternativeNanoyapılar kullanılarak immün yanıt tetiklenmesien_US
dc.typeThesisen_US
thesis.degree.disciplineNeuroscience
thesis.degree.grantorBilkent University
thesis.degree.levelMaster's
thesis.degree.nameMS (Master of Science)

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