Ischemic stroke phenotype in patients with nonsustained atrial fibrillation
buir.contributor.author | Atalar, Ergin | |
dc.citation.epage | 640 | en_US |
dc.citation.issueNumber | 3 | en_US |
dc.citation.spage | 634 | en_US |
dc.citation.volumeNumber | 46 | en_US |
dc.contributor.author | Arsava, E. M. | en_US |
dc.contributor.author | Bas, D. F. | en_US |
dc.contributor.author | Atalar, Ergin | en_US |
dc.contributor.author | Has, A. C. | en_US |
dc.contributor.author | Oguz, K. K. | en_US |
dc.contributor.author | Topcuoglu, M. A. | en_US |
dc.date.accessioned | 2016-02-08T09:58:56Z | |
dc.date.available | 2016-02-08T09:58:56Z | |
dc.date.issued | 2015 | en_US |
dc.department | National Magnetic Resonance Research Center (UMRAM) | en_US |
dc.description.abstract | Background and Purpose: The widespread use of ambulatory cardiac monitoring has not only increased the detection of high-risk arrhythmias like persistent and paroxysmal atrial fibrillation (AF), but also made it possible to identify other aberrations such as short-lasting (<30 seconds) irregular runs of supraventricular tachycardia. Ischemic stroke phenotype might be helpful in understanding whether these nonsustained episodes play a similar role in stroke pathophysiology like their persistent and paroxysmal counterparts. Methods: In a consecutive series of patients with ischemic stroke, we retrospectively determined clinical and imaging features associated with nonsustained AF (n=126), defined as <30-second-lasting supraventricular tachyarrhythmias with irregular RR interval on 24-hour Holter monitoring, and compared them to patients with persistent/paroxysmal AF (n=239) and no AF (n=246). Results: Patients with persistent/paroxysmal AF significantly differed from patients with nonsustained AF by a higher prevalence of female sex (odds ratio [95% confidence interval], 1.8 [1.1-2.9]), coronary artery disease (1.9 [1.1-3.0]), and embolic imaging features (2.7 [1.1-6.5]), and lower frequency of smoking (0.4 [0.2-0.8]) and hyperlipidemia (0.5 [0.3-0.8]). In contrast, patients with no AF were younger (0.5 [0.4-0.6] per decade) and more likely to be male (1.7 [1.0-2.8]) in comparison with nonsustained AF population. The prevalence of nonsustained AF was similar among cryptogenic and noncryptogenic stroke patients (32% versus 29%). Voxel-wise comparison of lesion probability maps revealed no significant difference between cryptogenic stroke patients with and without nonsustained AF. Conclusions: Clinical features of patients with nonsustained AF exhibited an intermediary phenotype in between patients with persistent/paroxysmal AF and no AF. Furthermore, imaging features did not entirely resemble patterns observed in patients with longer durations of AF. | en_US |
dc.description.provenance | Made available in DSpace on 2016-02-08T09:58:56Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2015 | en |
dc.identifier.doi | 10.1161/STROKEAHA.114.006396 | en_US |
dc.identifier.issn | 0039-2499 | |
dc.identifier.uri | http://hdl.handle.net/11693/22347 | |
dc.language.iso | English | en_US |
dc.publisher | Lippincott Williams and Wilkins | en_US |
dc.relation.isversionof | https://doi.org/10.1161/STROKEAHA.114.006396 | en_US |
dc.source.title | Stroke | en_US |
dc.subject | Ambulatory | en_US |
dc.subject | Atrial fibrillation | en_US |
dc.subject | Electrocardiography | en_US |
dc.subject | Magnetic resonance imaging | en_US |
dc.subject | Adult | en_US |
dc.subject | Aged | en_US |
dc.subject | Article | en_US |
dc.subject | Atherosclerosis | en_US |
dc.subject | Atrial fibrillation | en_US |
dc.subject | Brain ischemia | en_US |
dc.subject | Cerebrovascular accident | en_US |
dc.subject | Coronary artery disease | en_US |
dc.subject | Diabetes mellitus | en_US |
dc.subject | Female | en_US |
dc.subject | Holter monitoring | en_US |
dc.subject | Human | en_US |
dc.subject | Hyperlipidemia | en_US |
dc.subject | Hypertension | en_US |
dc.subject | Major clinical study | en_US |
dc.subject | Male | en_US |
dc.subject | Middle aged | en_US |
dc.subject | Persistent atrial fibrillation | en_US |
dc.subject | Phenotype | en_US |
dc.subject | Priority journal | en_US |
dc.subject | Retrospective study | en_US |
dc.subject | RR interval | en_US |
dc.subject | Smoking | en_US |
dc.subject | Stroke patient | en_US |
dc.subject | Supraventricular tachycardia | en_US |
dc.subject | Transient ischemic attack | en_US |
dc.subject | Very elderly | en_US |
dc.subject | Atrial fibrillation | en_US |
dc.subject | Brain ischemia | en_US |
dc.subject | Electrocardiography | en_US |
dc.subject | Pathophysiology | en_US |
dc.subject | Probability | en_US |
dc.subject | Procedures | en_US |
dc.subject | Tachycardia, Supraventricular | en_US |
dc.subject | Aged | en_US |
dc.subject | Aged, 80 and over | en_US |
dc.subject | Atrial Fibrillation | en_US |
dc.subject | Brain Ischemia | en_US |
dc.subject | Electrocardiography, Ambulatory | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Phenotype | en_US |
dc.subject | Probability | en_US |
dc.subject | Retrospective Studies | en_US |
dc.subject | Stroke | en_US |
dc.subject | Tachycardia | en_US |
dc.subject | Supraventricular | en_US |
dc.title | Ischemic stroke phenotype in patients with nonsustained atrial fibrillation | en_US |
dc.type | Article | en_US |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Ischemic_stroke_phenotype_in_patients_with_nonsustained_atrial_fibrillation.pdf
- Size:
- 5.03 MB
- Format:
- Adobe Portable Document Format
- Description:
- Full printable version