Exosomes: Natural nanovesicle candidates used in the diagnosis and treatment

dc.citation.epage40en_US
dc.citation.issueNumber2en_US
dc.citation.spage34en_US
dc.citation.volumeNumber2en_US
dc.contributor.authorKahraman, T.en_US
dc.contributor.authorGíiçlíiler G.en_US
dc.contributor.authorGürsel I.en_US
dc.date.accessioned2016-02-08T09:42:25Z
dc.date.available2016-02-08T09:42:25Z
dc.date.issued2013en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractExosomes are nano-vesicles released by all known cells. Although they were called as residual cells acting as a cleaner of undesired molecules out of cell during the first discovery in 1980s, recent studies have revealed critical physiological tasks of these vesicles over the past 20 years. These vesicles which can be produced by all body fluids play an important role in many biological activities including intracellular communication, signal conduction, genetic material transfer, and regulation of immune response. Due to their several tasks, exosomes play a crucial role in the disease pathogenesis. Considering all these tasks, exosomes can be considered in both diagnosis and treatment. Exosomes originating from distinct cells have immunosuppressive and immunostimulatory features and, thereby, therapeutic attempts which regulate immune function in case of autoimmune and immunosuppression. In addition, thanks to being natural nano-carriers, exosomes may pave the way for the development of new-generation vaccines containing both adjuvant and antigen. Besides therapeutic applications, there are evidences indicating that exosomes can be used in the diagnosis of several cancer forms including prostate cancer, glioblastoma, squamous-cell lung carcinoma and hepatocellular carcinoma, as they play a role in the disease pathogenesis. © 2014 Turkish Journal of Immunology.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:42:25Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2013en
dc.identifier.doi10.5606/tji.2014.323en_US
dc.identifier.issn1301109X
dc.identifier.urihttp://hdl.handle.net/11693/21173
dc.language.isoTurkishen_US
dc.publisherTurkish Society of Immunologyen_US
dc.relation.isversionofhttp://dx.doi.org/10.5606/tji.2014.323en_US
dc.source.titleTurkish Journal of Immunologyen_US
dc.subjectCanceren_US
dc.subjectDiagnosisen_US
dc.subjectExosome nano-vesicleen_US
dc.subjectImmunityen_US
dc.subjectTherapyen_US
dc.subjectArticleen_US
dc.subjectautoimmunityen_US
dc.subjectbody fluiden_US
dc.subjectcell communicationen_US
dc.subjectexosomeen_US
dc.subjectglioblastomaen_US
dc.subjecthumanen_US
dc.subjectimmune deficiencyen_US
dc.subjectimmune responseen_US
dc.subjectimmunostimulationen_US
dc.subjectliver cell carcinomaen_US
dc.subjectnanotechnologyen_US
dc.subjectnanovesicleen_US
dc.subjectprostate canceren_US
dc.subjectsignal transductionen_US
dc.subjectsquamous cell lung carcinomaen_US
dc.titleExosomes: Natural nanovesicle candidates used in the diagnosis and treatmenten_US
dc.title.alternativeEksozomlar: Tani ve tedavide kullanilabilen dogal nanokesecik adaylarien_US
dc.typeArticleen_US

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