Sulfatide mediates attachment of Pseudomonas aeruginosa to human pharyngeal epithelial cells

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dc.citation.epage171en_US
dc.citation.issueNumber2en_US
dc.citation.spage167en_US
dc.citation.volumeNumber30en_US
dc.contributor.authorYagci, A.en_US
dc.contributor.authorYagci, T.en_US
dc.contributor.authorSener, B.en_US
dc.contributor.authorSuziki, Y.en_US
dc.contributor.authorAhmed, K.en_US
dc.date.accessioned2016-02-08T10:14:59Z
dc.date.available2016-02-08T10:14:59Z
dc.date.issued2007en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractPseudomonas aeruginosa infections are particularly common in people with cystic fibrosis and despite regular treatment with antibiotics, lung damage due to chronic infection with P. aeruginosa remains the major cause of death in those patients. In order to initiate an infection, P. aeruginosa needs contact with the respiratory epithelial surface and by means of its adhesins i.e., fimbria, hemagglutinins,etc., it recognizes and adheres to the corresponding epithelial receptors. We treated P. aeruginosa strains isolated from sputum of cystic fibrosis patients with several glycolipids such as sulfatide, sulfated ganglioside mixture (GM1a, GD1b, GT1b), asialo-GM1 and galactocerebrosides to determine their effect on attachment with pharyngeal epithelial cells. Sulfated ganglioside mixture and sulfatide inhibited the attachment of P. aeruginosa significantly, whereas asialo-GM1, Gal-Cer and sodium sulfite had no effect on attachment inhibition. This finding suggests that sulfated glycoconjugates found in the extracellular matrix, in mucus and on the surface of epithelial cells of human trachea and lung mediates attachment of P. aeruginosa.en_US
dc.identifier.issn1121-7138
dc.identifier.urihttp://hdl.handle.net/11693/23507
dc.language.isoEnglishen_US
dc.publisherEdizioni Medico Scientificheen_US
dc.source.titleNew Microbiologicaen_US
dc.subjectAsialo-GM 1en_US
dc.subjectAttachmenten_US
dc.subjectEpithelial cellsen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectSulfatideen_US
dc.subjectPseudomonas aeruginosaen_US
dc.titleSulfatide mediates attachment of Pseudomonas aeruginosa to human pharyngeal epithelial cellsen_US
dc.typeArticleen_US

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