Optimization and machine learning in MRI: applications in rapid MR image reconstruction and encoding models of cortical representations

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buir.advisorÇukur, Tolga
dc.contributor.authorShahdloo, Mohammad
dc.date.accessioned2020-03-06T13:53:33Z
dc.date.available2020-03-06T13:53:33Z
dc.date.copyright2020-02
dc.date.issued2020-02
dc.date.submitted2020-03-06
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (Ph.D.): Bilkent University, Department of Electrical and Electronics Engineering, İhsan Doğramacı Bilkent University, 2020.en_US
dc.descriptionIncludes bibliographical references (leaves 116-142).en_US
dc.description.abstractMagnetic Resonance Imaging (MRI) is a non-invasive medical imaging modality that is widely used by clinicians and researchers to picture body anatomy and neuronal function. However, long scan time remains a major problem. Recently, multiple techniques have emerged that reduce the acquired MRI signal samples, hence dramatically accelerating the acquisition. These techniques involve sophisticated signal reconstruction procedures that in essence require solving regularized optimization problems, and clinical adoption of accelerated MRI critically relies on self-tuning solutions for these problems. Further to this, recent experimental approaches in cognitive neuroscience favor employing naturalistic audio-visual stimuli that closely resemble humans’ daily-life experience. Yet, these modern paradigms inevitably lead to huge functional MRI (fMRI) datasets that require advanced statistical and computational techniques to uncover the large amount of embedded information. Here, we propose a novel efficient datadriven self-tuning reconstruction method for accelerated MRI. We demonstrate superior performance of the proposed method across various simulated and in vivo datasets and under various scan configurations. Furthermore, we develop statistical analysis tools to investigate the neural representation of hundreds of action categories in natural movies in the brain via fMRI, and study their attentional modulations. Finally, we develop a model-based framework to estimate temporal extent of semantic information integration in the brain, and investigate its attentional modulations using fMRI data recorded during natural story listening. In short, the methodological and analytical approaches introduced in this thesis greatly benefit clinical utility of accelerated MRI, and enhance our understanding of brain function in daily life.en_US
dc.description.degreePh.D.en_US
dc.description.statementofresponsibilityby Mohammad Shahdlooen_US
dc.embargo.release2020-09-06
dc.format.extentxiv, 142 leaves : illustrations (some color), charts (some color) ; 30 cm.en_US
dc.identifier.itemidB160223
dc.identifier.urihttp://hdl.handle.net/11693/53514
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMagnetic resonance imaging (MRI)en_US
dc.subjectSelf-tuning reconstructionen_US
dc.subjectEncoding modelsen_US
dc.subjectAction perceptionen_US
dc.subjectDeep learningen_US
dc.subjectLanguage modelen_US
dc.titleOptimization and machine learning in MRI: applications in rapid MR image reconstruction and encoding models of cortical representationsen_US
dc.title.alternativeMRG’de optimizasyon ve makine öğrenimi: hızlı MR görüntü rekonstrüksiyonu ve beyindeki temsillerin kodlama modellerine uygulanışıen_US
dc.typeThesisen_US

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