Purinergic regulation of the immune system

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dc.citation.epage192en_US
dc.citation.issueNumber3en_US
dc.citation.spage177en_US
dc.citation.volumeNumber16en_US
dc.contributor.authorCekic, C.en_US
dc.contributor.authorLinden, J.en_US
dc.date.accessioned2018-04-12T13:49:44Z
dc.date.available2018-04-12T13:49:44Z
dc.date.issued2016en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractCellular stress or apoptosis triggers the release of ATP, ADP and other nucleotides into the extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling molecules by activating cell-surface P2 purinergic receptors that elicit pro-inflammatory immune responses. Over time, extracellular nucleotides are metabolized to adenosine, leading to reduced P2 signalling and increased signalling through anti-inflammatory adenosine (P1 purinergic) receptors. Here, we review how local purinergic signalling changes over time during tissue responses to injury or disease, and we discuss the potential of targeting purinergic signalling pathways for the immunotherapeutic treatment of ischaemia, organ transplantation, autoimmunity or cancer.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T13:49:44Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016en
dc.identifier.doi10.1038/nri.2016.4en_US
dc.identifier.issn1474-1733
dc.identifier.urihttp://hdl.handle.net/11693/38167
dc.language.isoEnglishen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttps://doi.org/10.1038/nri.2016.4en_US
dc.source.titleNature Reviews Immunologyen_US
dc.subjectAdenosineen_US
dc.subjectAdenosine A2 receptoren_US
dc.subjectAdenosine A2b receptoren_US
dc.subjectAdenosine diphosphateen_US
dc.subjectAdenosine triphosphateen_US
dc.subjectNucleotideen_US
dc.subjectPurinergic P2 receptoren_US
dc.subjectPurinergic P2X receptoren_US
dc.subjectPurinergic P2Y receptoren_US
dc.subjectPurine derivativeen_US
dc.subjectAutoimmunityen_US
dc.subjectEffector cellen_US
dc.subjectExtracellular spaceen_US
dc.subjectGraft rejectionen_US
dc.subjectHeart muscle ischemiaen_US
dc.subjectImmune systemen_US
dc.subjectImmunocompetent cellen_US
dc.subjectImmunotherapyen_US
dc.subjectKidney ischemiaen_US
dc.subjectMacrophageen_US
dc.subjectMonocyteen_US
dc.subjectNatural killer T cellen_US
dc.subjectNeoplasmen_US
dc.subjectNeutrophilen_US
dc.subjectNonhumanen_US
dc.subjectOrgan transplantationen_US
dc.subjectPneumoniaen_US
dc.subjectPriority journalen_US
dc.subjectRegulatory T lymphocyteen_US
dc.subjectReviewen_US
dc.subjectSignal transductionen_US
dc.subjectT lymphocyteen_US
dc.subjectTissue injuryen_US
dc.subjectTissue reactionen_US
dc.subjectAdaptive immunityen_US
dc.subjectAnimalen_US
dc.subjectHumanen_US
dc.subjectImmunologyen_US
dc.subjectInnate immunityen_US
dc.subjectAdaptive Immunityen_US
dc.subjectAnimalsen_US
dc.subjectHumansen_US
dc.subjectImmunity, Innateen_US
dc.subjectPurinesen_US
dc.subjectSignal Transductionen_US
dc.titlePurinergic regulation of the immune systemen_US
dc.typeReviewen_US

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