Metabolomic profile of aggressive meningiomas by using highresolution magic angle spinning nuclear magnetic resonance

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buir.contributor.authorÇiçek, A. Ercüment
dc.citation.epage299en_US
dc.citation.issueNumber1en_US
dc.citation.spage292en_US
dc.citation.volumeNumber19en_US
dc.contributor.authorBender, L.en_US
dc.contributor.authorSomme, F.en_US
dc.contributor.authorRuhland, E.en_US
dc.contributor.authorÇiçek, A. Ercümenten_US
dc.contributor.authorBund, C.en_US
dc.contributor.authorNamer, I. J.en_US
dc.date.accessioned2021-02-11T06:48:36Z
dc.date.available2021-02-11T06:48:36Z
dc.date.issued2020
dc.departmentDepartment of Computer Engineeringen_US
dc.description.abstractMeningiomas are in most cases benign brain tumors. The WHO 2016 classification defines three grades of meningiomas. This classification had a prognosis value because grade III meningiomas have a worse prognosis value compared to grades I and II meningiomas. However, some benign or atypical meningiomas can have a clinical aggressive behavior. There are currently no reliable markers which allow distinguishing between the meningiomas with a good prognosis and those which may recur. High-resolution magic angle spinning (HRMAS) spectrometry is a noninvasive method able to determine the metabolite profile of a tissue sample. We retrospectively analyzed 62 meningioma samples by using HRMAS spectrometry (43 metabolites). We described a metabolic profile defined by a high concentration for acetate, threonine, N-acetyl-lysine, hydroxybutyrate, myoinositol, ascorbate, scylloinositol, and total choline and a low concentration for aspartate, glucose, isoleucine, valine, adenosine, arginine, and alanine. This metabolomic signature was associated with poor prognosis histological markers [Ki-67 ≥ 40%, high histological grade and negative progesterone receptor (PR) expression]. We also described a similar metabolomic spectrum between grade III and grade I meningiomas. Moreover, all grade I meningiomas with a low Ki-67 expression and a positive PR expression did not have the same metabolomic profile. Metabolomic analysis could be used to determine an aggressive meningioma in order to discuss a personalized treatment. Further studies are needed to confirm these results and to correlate this metabolic profile with survival data.en_US
dc.identifier.doi10.1021/acs.jproteome.9b00521en_US
dc.identifier.issn1535-3893
dc.identifier.urihttp://hdl.handle.net/11693/55059
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttps://dx.doi.org/10.1021/acs.jproteome.9b00521en_US
dc.source.titleJournal of Proteome Researchen_US
dc.subjectEx vivo spectrometryen_US
dc.subjectHRMAS NMRen_US
dc.subjectMeningiomaen_US
dc.subjectMetabolic signatureen_US
dc.titleMetabolomic profile of aggressive meningiomas by using highresolution magic angle spinning nuclear magnetic resonanceen_US
dc.typeArticleen_US

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