Congenital pineoblastoma and parameningeal rhabdomyosarcoma: concurrent two embryonal tumors in a young infant

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buir.contributor.authorÜren, Deniz
dc.citation.epage538en_US
dc.citation.issueNumber5en_US
dc.citation.spage533en_US
dc.citation.volumeNumber22en_US
dc.contributor.authorÇorapçıoğlu, F.en_US
dc.contributor.authorÖzek, M. M.en_US
dc.contributor.authorSav, A.en_US
dc.contributor.authorÜren, Denizen_US
dc.date.accessioned2016-02-08T10:19:32Z
dc.date.available2016-02-08T10:19:32Z
dc.date.issued2006en_US
dc.departmentGenetics and Biotechnology Research Center (BİLGEN)en_US
dc.description.abstractBackground: Pineoblastomas are very rare brain tumors in fetus and neonates, comprising only 0.9% of congenital brain tumors. The occurrence of multiple tumors of different histopathologic types in the same individual is a rare event, most often encountered in hereditary cancer syndromes. Case Report: We report a female fetus presented with a congenital pineoblastoma at the 32nd week of gestation, with hydrocephalus and concurrent parameningeal embryonal rhabdomyosarcoma in early infancy. Results: Cytogenetic analysis showed normal karyotype in the peripheral blood of the patient, and p53 mutational analysis revealed no germ line mutations. Discussion: This is the first case with concurrent congenital pineoblastoma and parameningeal embryonal rhabdomyosarcoma in early infancy. We suggest that concurrence of these tumors could be due to mutations in other tumor suppressor genes or secondary to exposure to unknown in utero factors.en_US
dc.identifier.doi10.1007/s00381-005-0006-2en_US
dc.identifier.issn0256-7040
dc.identifier.urihttp://hdl.handle.net/11693/23811
dc.language.isoEnglishen_US
dc.publisherSpringeren_US
dc.relation.isversionofhttps://doi.org/10.1007/s00381-005-0006-2en_US
dc.source.titleChild's Nervous Systemen_US
dc.subjectBrain tumoren_US
dc.subjectCongenitalen_US
dc.subjectp53 gene mutationen_US
dc.subjectPineoblastomaen_US
dc.subjectRhabdomyosarcomaen_US
dc.titleCongenital pineoblastoma and parameningeal rhabdomyosarcoma: concurrent two embryonal tumors in a young infanten_US
dc.typeArticleen_US

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