MEFV gene is a probable susceptibility gene for Behçet's disease

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dc.citation.epage58en_US
dc.citation.issueNumber1en_US
dc.citation.spage56en_US
dc.citation.volumeNumber34en_US
dc.contributor.authorImirzalıoglu, N.en_US
dc.contributor.authorDursun, A.en_US
dc.contributor.authorTastan, B.en_US
dc.contributor.authorSoysal, Y.en_US
dc.contributor.authorYakıcıer, M. C.en_US
dc.date.accessioned2016-02-08T10:23:46Z
dc.date.available2016-02-08T10:23:46Z
dc.date.issued2005en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractObjective: Behçet's disease (BD) is a rare, chronic, multisystem inflammatory disorder. The prevalence of BD is higher in the Middle Eastern and Mediterranean populations. Another chronic inflammatory disease, familial Mediterranean fever (FMF), is also known to be highly prevalent in these populations. The prevalence of BD is higher in the FMF patient population than in populations known to be rich in BD. Both BD and FMF have some pathophysiological features in common and they result from inappropriate activation of neutrophils. Clinical manifestations of both diseases can mimic each other and the coexistence of both diseases in the same patient has been reported. Given that BD and FMF have similar pathophysiological, epidemiological, and clinical features, we hypothesized that the gene responsible for FMF, MEFV, may also play a role in the pathogenesis of BD. Methods: Forty-two BD patients who had no symptoms and family history for FMF and 66 healthy controls were screened for common MEFV gene mutations (E148Q, M680I, M694V, and V726A). Results: Fifteen patients (36%) displayed MEFV mutations (nine M694V, five E148Q, and one M680I) and mutation rates were significantly elevated compared to 66 (11%) healthy controls (p=0.0034). Conclusion: The occurrence of frequent MEFV mutations in BD patients suggests that the MEFV gene is involved in the pathogenesis of Behçet's disease. © 2005 Taylor & Francis.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:23:46Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2005en
dc.identifier.doi10.1080/03009740510017931en_US
dc.identifier.issn0300-9742
dc.identifier.urihttp://hdl.handle.net/11693/24078
dc.language.isoEnglishen_US
dc.publisherTaylor & Francisen_US
dc.relation.isversionofhttp://dx.doi.org/10.1080/03009740510017931en_US
dc.source.titleScandinavian Journal of Rheumatologyen_US
dc.subjectBehcet diseaseen_US
dc.subjectClinical articleen_US
dc.subjectClinical featureen_US
dc.subjectControlled studyen_US
dc.subjectDisease associationen_US
dc.subjectFamilial Mediterranean feveren_US
dc.titleMEFV gene is a probable susceptibility gene for Behçet's diseaseen_US
dc.typeArticleen_US

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