One-pot synthesis of hybrid core-shell nanoparticles for antibacterial photodynamic therapy

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buir.advisorTuncel, Dönüş
dc.contributor.authorHadi, Seyed Ehsan
dc.date.accessioned2019-08-23T06:08:10Z
dc.date.available2019-08-23T06:08:10Z
dc.date.copyright2019-07
dc.date.issued2019-07
dc.date.submitted2019-08-21
dc.departmentGraduate Program in Materials Science and Nanotechnologyen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (M.S.): Bilkent University, Department of Materials Science and Nanotechnology, İhsan Doğramacı Bilkent University, 2019.en_US
dc.descriptionIncludes bibliographical references (leaves 105-121).en_US
dc.description.abstractMultidrug resistance (MDR) in Escherichia coli (E. coli) has become a worrying issue that is not only increasingly observed in humans but also is widespread in veterinary medicine worldwide. Therefore, developing new and e ective alternatives to conventional antibiotics has become an imperative need. The idea of using photodynamic therapy (PDT) for bacterial eradication is a solution for the cases that the bacteria are resisting to conventional antibiotics. Although in these cases, PDT can be an option, PDT-killing efficiency might still not be sufficient, and some enhancements are necessary. Metal-enhanced singlet oxygen generation (ME1O2) is one of the ways to enhance the PDT-killing efficiency of the E. coli. Hybrid core-shell structures can serve conveniently for this purpose. These structures can combine the exible and tailorable features of polymers (shell) with the photophysical properties of plasmonic metals (core). In this work, using gold as a core and conjugated oligomer as a shell produced a novel hybrid core-shell nanoparticles which can enhance the singlet oxygen generation capacity and subsequently, improve the PDT-killing efficiency of the E. coli. In this structure, the shell is responsible for the spontaneous reduction of gold ions, forming gold nanoparticles and protecting them from the aggregation. With further investigation and optimization, the hybrid core-shell nanoparticles with the help of ME1O2 successfully improved the killing efficiency of E. coli bacteria by 40%.en_US
dc.description.degreeM.S.en_US
dc.description.provenanceSubmitted by Betül Özen (ozen@bilkent.edu.tr) on 2019-08-23T06:08:10Z No. of bitstreams: 1 thesis.pdf: 32215762 bytes, checksum: 124b37fa6090a039aa2f18688757756b (MD5)en
dc.description.provenanceMade available in DSpace on 2019-08-23T06:08:10Z (GMT). No. of bitstreams: 1 thesis.pdf: 32215762 bytes, checksum: 124b37fa6090a039aa2f18688757756b (MD5) Previous issue date: 2019-08en
dc.description.statementofresponsibilityby Seyed Ehsan Hadien_US
dc.embargo.release2020-02-21
dc.format.extentxvi, 121 leaves : illustrations (some color), charts (some color) ; 30 cm.en_US
dc.identifier.itemidB105351
dc.identifier.urihttp://hdl.handle.net/11693/52358
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCore-shell nanoparticleen_US
dc.subjectAntibacterial photodynamic therapyen_US
dc.subjectMetalenhanced singlet oxygen generation, ROSen_US
dc.subjectE. colien_US
dc.subjectConjugated oligomeren_US
dc.subjectGold nanoparticleen_US
dc.titleOne-pot synthesis of hybrid core-shell nanoparticles for antibacterial photodynamic therapyen_US
dc.title.alternativeAntibakteriyel fotodinamik tedaviye yönelik hibrit çekirdek-kabuk nanoparçacıklarının tek adımda sentezien_US
dc.typeThesisen_US

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