Synthesis of BODIPY conjugates towards multimodal therapeutic applicaitons

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buir.advisorAkkaya, Engin U.
dc.contributor.authorOkeev, Darika
dc.date.accessioned2016-09-05T06:57:07Z
dc.date.available2016-09-05T06:57:07Z
dc.date.copyright2016-08
dc.date.issued2016-08
dc.date.submitted2016-09-02
dc.departmentDepartment of Chemistryen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (M.S.): Bilkent University, Department of Chemistry, İhsan Doğramacı Bilkent University, 2016.en_US
dc.descriptionIncludes bibliographical references (leaves 46-52).en_US
dc.description.abstractPhotodynamic therapy (PDT) is a promising and developing strategy to treat various types of cancers. Either on its own, or combined with surgical interference, it provides easy treatment without destructive side effects of chemotherapy. Its success is straightly dependent on the presence of singlet oxygen (SO) in the tumor tissues. Upon the activation of the photosensitizer, SO gets produced, harming the surrounding tissues. The destructive effect can be increased by a simultaneous treatment with a cytotoxic cancer drug. In this project, we have combined a BODIPY photosensitizer and a Camptothecin (CPT) drug moiety with a (Z)-1,2-bis(alkyl-thio)ethane linker to produce a macromolecule with higher destructive power for tumors. Upon irradiation with a light source, it is expected of the BODIPY sensitizer to convert triplet ground state oxygen to singlet excited state, which then would react with the linker to release CPT.en_US
dc.description.degreeM.S.en_US
dc.description.statementofresponsibilityby Darika Okeev.en_US
dc.embargo.release2018-09-02
dc.format.extentxii, 85 leaves : illustrations, charts, graphics.en_US
dc.identifier.itemidB154010
dc.identifier.urihttp://hdl.handle.net/11693/32192
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectBODIPYen_US
dc.subjectSinglet oxygenen_US
dc.subjectCamptothecinen_US
dc.subjectLinkeren_US
dc.titleSynthesis of BODIPY conjugates towards multimodal therapeutic applicaitonsen_US
dc.title.alternativeMultimodlu tedavi uygulamalarına yönelik BODIPY türevlerinin sentezien_US
dc.typeThesisen_US

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