Rational vaccine design in times of emerging diseases: The critical choices of immunological correlates of protection, vaccine antigen and immunomodulation

Simple item page
buir.contributor.authorGürsel, İhsan
buir.contributor.orcidGürsel, İhsan|0000-0003-3761-1166
dc.citation.epage29en_US
dc.citation.issueNumber4en_US
dc.citation.spage1en_US
dc.citation.volumeNumber13en_US
dc.contributor.authorSchijns, V.
dc.contributor.authorMajhen, D.
dc.contributor.authorLey, P.
dc.contributor.authorThakur, A.
dc.contributor.authorSummerfield, A.
dc.contributor.authorBerisio, R.
dc.contributor.authorNativi, C.
dc.contributor.authorFernández-Tejada, A.
dc.contributor.authorAlvarez-Dominguez, C.
dc.contributor.authorGizurarson, S.
dc.contributor.authorZamyatina, A.
dc.contributor.authorMolinaro, A.
dc.contributor.authorRosano, C.
dc.contributor.authorJakopin, Z.
dc.contributor.authorMcClean, S.
dc.contributor.authorGürsel, İhsan
dc.date.accessioned2022-02-10T11:39:16Z
dc.date.available2022-02-10T11:39:16Z
dc.date.issued2021-04-06
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractVaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines can allow us to optimise their efficacy, by tailoring the immune response. Establishing the immune correlates of protection greatly informs the rational design of vaccines. This facilitates the selection of the best vaccine antigens and the most appropriate vaccine adjuvant to generate optimal memory immune T cell and B cell responses. This review outlines the range of vaccine types that are currently authorised and those under development. We outline the optimal immunological correlates of protection that can be targeted. Finally we review approaches to rational antigen selection and rational vaccine adjuvant design. Harnessing current knowledge on protective immune responses in combination with critical vaccine components is imperative to the prevention of future life-threatening diseases.en_US
dc.identifier.doi10.3390/pharmaceutics13040501en_US
dc.identifier.eissn1999-4923
dc.identifier.urihttp://hdl.handle.net/11693/77226
dc.language.isoEnglishen_US
dc.publisherMDPI AGen_US
dc.relation.isversionofhttps://doi.org/10.3390/pharmaceutics13040501en_US
dc.source.titlePharmaceuticsen_US
dc.subjectRationalen_US
dc.subjectVaccineen_US
dc.subjectDesignen_US
dc.subjectAntigenen_US
dc.subjectAdjuvanten_US
dc.subjectDelivery systemen_US
dc.subjectRouteen_US
dc.subjectImmunizationen_US
dc.titleRational vaccine design in times of emerging diseases: The critical choices of immunological correlates of protection, vaccine antigen and immunomodulationen_US
dc.typeReviewen_US

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Rational_vaccine_design_in_times_of_emerging_diseases_The_critical_choices_of_immunological_correlates_of_protection,_vaccine_antigen_and_immunomodulation.pdf
Size:
2.46 MB
Format:
Adobe Portable Document Format
Description:
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.69 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Scholarly Publications - Molecular Biology and Genetics