Interleukin-7 protects CD8+ T cells from adenosine-mediated immunosuppression

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buir.contributor.authorKoyaş, Altay
buir.contributor.authorTüçer, Suat
buir.contributor.authorKayhan, Merve
buir.contributor.authorSavaş, Ali Can
buir.contributor.authorAkdemir, İmran
buir.contributor.authorÇekiç, Çağlar
buir.contributor.orcidKoyaş, Altay|0000-0002-5436-6038
buir.contributor.orcidTüçer, Suat|0000-0002-6629-0093
buir.contributor.orcidKayhan, Merve|0000-0001-6089-5086
buir.contributor.orcidSavaş, Ali Can|0000-0002-2630-9765
buir.contributor.orcidAkdemir, İmran|0000-0002-8540-6741
buir.contributor.orcidÇekiç, Çağlar|0000-0001-8081-508X
dc.citation.epage8en_US
dc.citation.issueNumber674en_US
dc.citation.spage1en_US
dc.citation.volumeNumber14en_US
dc.contributor.authorKoyaş, Altay
dc.contributor.authorTüçer, Suat
dc.contributor.authorKayhan, Merve
dc.contributor.authorSavaş, Ali Can
dc.contributor.authorAkdemir, İmran
dc.contributor.authorÇekiç, Çağlar
dc.date.accessioned2022-01-27T12:12:11Z
dc.date.available2022-01-27T12:12:11Z
dc.date.issued2021-03-16
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractThe nucleoside adenosine accumulates extracellularly in solid tumors and inhibits CD8+ T cells by activating adenosine receptors. The cytokine interleukin-7 (IL-7), which is produced by various tissues and tumors, promotes the survival and maintenance of T cells. Adenosine and IL-7 signaling are being clinically targeted separately or in combination with other therapies for solid tumor indications. Here, we found that IL-7 signaling promoted the accumulation of tumor-associated CD8+ T cells, in part, by preventing adenosine-mediated immunosuppression. Inhibition of the transcription factor FoxO1 downstream of IL-7 receptor signaling was important for protecting CD8+ T cells from suppression by adenosine. These findings have implications for the development of new approaches for cancer immunotherapies that target the adenosine pathway.en_US
dc.identifier.doi10.1126/scisignal.abb1269en_US
dc.identifier.eissn1937-9145
dc.identifier.issn1945-0877
dc.identifier.urihttp://hdl.handle.net/11693/76840
dc.language.isoEnglishen_US
dc.publisherAmerican Association for the Advancement of Science (AAAS)en_US
dc.relation.isversionofhttps://dx.doi.org/10.1126/scisignal.abb1269en_US
dc.source.titleScience Signalingen_US
dc.titleInterleukin-7 protects CD8+ T cells from adenosine-mediated immunosuppressionen_US
dc.typeArticleen_US

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