Frequent demonstration of human herpesvirus 8 (HHV-8) in bone marrow biopsy samples from Turkish patients with multiple myeloma (MM)
dc.citation.epage | 1273 | en_US |
dc.citation.issueNumber | 8 | en_US |
dc.citation.spage | 1268 | en_US |
dc.citation.volumeNumber | 15 | en_US |
dc.contributor.author | Beksac, M. | en_US |
dc.contributor.author | Ma, M. | en_US |
dc.contributor.author | Akyerli, C. | en_US |
dc.contributor.author | DerDanielian, M. | en_US |
dc.contributor.author | Zhang, L. | en_US |
dc.contributor.author | Liu, J. | en_US |
dc.contributor.author | Arat, M. | en_US |
dc.contributor.author | Konuk, N. | en_US |
dc.contributor.author | Koc, H. | en_US |
dc.contributor.author | Ozcelik, T. | en_US |
dc.contributor.author | Vescio, R. | en_US |
dc.contributor.author | Berenson, J. R. | en_US |
dc.date.accessioned | 2016-02-08T10:34:44Z | |
dc.date.available | 2016-02-08T10:34:44Z | |
dc.date.issued | 2001 | en_US |
dc.department | Department of Molecular Biology and Genetics | en_US |
dc.description.abstract | In order to investigate the frequency of HHV-8 in MM patients from another geographic location, we obtained fresh bone marrow (BM) biopsies from Turkish patients with MM (n = 21), monoclonal gammopathy of undetermined significance (MGUS) (n = 2), plasmacytoma (n = 1) with BM plasma cell infiltration, various hematological disorders (n = 6), and five healthy Turkish controls. The frequency of HHV-8 was analyzed by polymerase chain reaction (PCR) in two independent laboratories in the USA and in Turkey. Using fresh BM biopsies, 17/21 MM patients were positive for HHV-8 whereas all five healthy controls, and six patients with other hematological disorders were negative. Two patients with MGUS, and one patient with a solitary plasmacytoma were also negative. The data from the two laboratories were completely concordant. Also using primer pairs for v IRF and v IL-8R confirmed the results observed with the KS330233 primers. Furthermore, sequence analysis demonstrated a C3 strain pattern in the ORF26 region which was also found in MM patients from the US. Thus, HHV-8 is present in the majority of Turkish MM patients, and the absence of the virus in healthy controls further supports its role in the pathogenesis of MM. | en_US |
dc.description.provenance | Made available in DSpace on 2016-02-08T10:34:44Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2001 | en |
dc.identifier.doi | 10.1038/sj.leu.2402190 | en_US |
dc.identifier.issn | 0887-6924 | |
dc.identifier.uri | http://hdl.handle.net/11693/24811 | |
dc.language.iso | English | en_US |
dc.publisher | Nature Publishing | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1038/sj.leu.2402190 | en_US |
dc.source.title | Leukemia | en_US |
dc.subject | Frequency and sequence | en_US |
dc.subject | HHV-8 | en_US |
dc.subject | Multiple myeloma | en_US |
dc.subject | Turkish patients | en_US |
dc.subject | Immunoglobulin heavy chain | en_US |
dc.subject | Immunoglobulin receptor | en_US |
dc.subject | Interleukin 8 receptor | en_US |
dc.subject | Plasma protein | en_US |
dc.subject | Primer DNA | en_US |
dc.subject | Basement membrane | en_US |
dc.subject | Bone marrow biopsy | en_US |
dc.subject | Cell infiltration | en_US |
dc.subject | Clinical article | en_US |
dc.subject | Controlled study | en_US |
dc.subject | Frequency analysis | en_US |
dc.subject | Geographic distribution | en_US |
dc.subject | Hematologic disease | en_US |
dc.subject | Human herpesvirus 8 | en_US |
dc.subject | Human tissue | en_US |
dc.subject | Laboratory test | en_US |
dc.subject | Monoclonal immunoglobulinemia | en_US |
dc.subject | Multiple myeloma | en_US |
dc.subject | Nonhuman | en_US |
dc.subject | Open reading frame | en_US |
dc.subject | Pathogenesis | en_US |
dc.subject | Plasma cell | en_US |
dc.subject | Plasmacytoma | en_US |
dc.subject | Polymerase chain reaction | en_US |
dc.subject | Priority journal | en_US |
dc.subject | Sequence analysis | en_US |
dc.subject | Turkey (republic) | en_US |
dc.subject | United States | en_US |
dc.subject | Virus detection | en_US |
dc.subject | Virus strain | en_US |
dc.subject | Biopsy | en_US |
dc.subject | Bone Marrow | en_US |
dc.subject | Herpesviridae infections | en_US |
dc.subject | Herpesvirus 8, human | en_US |
dc.subject | Humans | en_US |
dc.subject | Multiple Myeloma | en_US |
dc.subject | Turkey | en_US |
dc.title | Frequent demonstration of human herpesvirus 8 (HHV-8) in bone marrow biopsy samples from Turkish patients with multiple myeloma (MM) | en_US |
dc.type | Article | en_US |
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