Elucidation of the role of IKK-related kinases in ulcerative colitis

Abstract

Ulcerative colitis is an inflammatory disease of the colon resulting from the imbalance of the inflammatory mechanisms. Its onset and development depend on multiple factors, which are not yet fully uncovered. Understanding the factors involved in the pathophysiology of ulcerative colitis is important for the management of the disease. IKK-related kinases are involved in numerous pathways in cellular signaling. They play significant roles in the modulation of the inflammatory responses. In this study, we investigated the roles played by IKK-related kinases in ulcerative colitis. We generated DSS-induced colitis mouse models in acute and chronic phases. We treated these mice with a dual IKK-related kinase inhibitor, Amlexanox, to understand the role played by these kinases on the onset and development of the condition. Moreover, we performed biochemical analyses on the samples to gain molecular insights. We observed an increased inflammatory response both phenotypically and biochemically upon inhibition of IKK-related kinases.