Engineering red-emitting multi-functional nanocapsules for magnetic tumour targeting and imaging

buir.contributor.authorKhan, Rehan
buir.contributor.authorBazzar, Maasoomeh
buir.contributor.authorTuncel, Dönüş
dc.citation.epage2599en_US
dc.citation.issueNumber9en_US
dc.citation.spage2590en_US
dc.citation.volumeNumber8en_US
dc.contributor.authorWang, J. T.-W.
dc.contributor.authorMartino, U.
dc.contributor.authorKhan, Rehan
dc.contributor.authorBazzar, Maasoomeh
dc.contributor.authorSouthern, P.
dc.contributor.authorTuncel, Dönüş
dc.contributor.authorAl-Jamal, K. T.
dc.date.accessioned2021-02-26T19:22:23Z
dc.date.available2021-02-26T19:22:23Z
dc.date.issued2020-03
dc.departmentDepartment of Chemistryen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractIn this work we describe the formulation and characterisation of red-emitting polymeric nanocapsules (NCs) incorporating superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic tumour targeting. The self-fluorescent oligomers were synthesised and chemically conjugated to PLGA which was confirmed by NMR spectroscopy, FT-IR spectroscopy and mass spectrometry. Hydrophobic SPIONs were synthesised through thermal decomposition and their magnetic and heating properties were assessed by SQUID magnetometry and calorimetric measurements, respectively. Magnetic nanocapsules (m-NCs) were prepared by a single emulsification/solvent evaporation method. Their in vitro cytotoxicity was examined in CT26 colon cancer cells. The formulated fluorescent m-NCs showed good stability and biocompatibility both in vitro and in vivo in CT 26 colon cancer models. Following intravenous injection, accumulation of m-NCs in tumours was observed by optical imaging. A higher iron content in the tumours exposed to a magnetic field, compared to the contralateral tumours without magnetic exposure in the same animal, further confirmed the magnetic tumour targeting in vivo. The overall results show that the engineered red-emitting m-NCs have great potential as multifunctional nanocarriers for multi-model bioimaging and magnetic-targeted drug delivery.en_US
dc.description.provenanceSubmitted by Evrim Ergin (eergin@bilkent.edu.tr) on 2021-02-26T19:22:23Z No. of bitstreams: 1 Engineering_red-emitting_multi-functional_nanocapsules_for_magnetic_tumour_targeting_and_imaging.pdf: 2051941 bytes, checksum: f9f838b20551a9b9bdbfd7e8f4dcea5f (MD5)en
dc.description.provenanceMade available in DSpace on 2021-02-26T19:22:23Z (GMT). No. of bitstreams: 1 Engineering_red-emitting_multi-functional_nanocapsules_for_magnetic_tumour_targeting_and_imaging.pdf: 2051941 bytes, checksum: f9f838b20551a9b9bdbfd7e8f4dcea5f (MD5) Previous issue date: 2020-03en
dc.identifier.doi10.1039/D0BM00314Jen_US
dc.identifier.issn0003-2654
dc.identifier.urihttp://hdl.handle.net/11693/75615
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttps://doi.org/10.1039/D0BM00314Jen_US
dc.source.titleBiomaterials Scienceen_US
dc.titleEngineering red-emitting multi-functional nanocapsules for magnetic tumour targeting and imagingen_US
dc.typeArticleen_US

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