Extremely skewed X-chromosome inactivation is increased in pre-eclampsia

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dc.citation.epage105en_US
dc.citation.issueNumber1en_US
dc.citation.spage101en_US
dc.citation.volumeNumber121en_US
dc.contributor.authorUz, E.en_US
dc.contributor.authorDolen, I.en_US
dc.contributor.authorAl, A. R.en_US
dc.contributor.authorOzcelik, T.en_US
dc.date.accessioned2015-07-28T11:58:04Z
dc.date.available2015-07-28T11:58:04Z
dc.date.issued2007-03en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractPre-eclampsia is a disorder that affects approximately 5% of pregnancies. We tested the hypothesis that skewed X-chromosome inactivation (XCI) could be involved in the pathogenesis of pre-eclampsia. Peripheral blood DNA was obtained from 67 pre-eclampsia patients and 130 control women. Androgen receptor (AR) was analyzed by the Hpa II/polymerase chain reaction assay to assess XCI patterns in DNA extracted from peripheral-blood cells. In addition, buccal cells were obtained from seven patients, and the analysis repeated. Extremely skewed XCI was observed in 10 of 46 informative patients (21.74%), and in 2 of 86 informative controls (2.33%, P = 0.0005; χ2 test). Our findings support a role for the X-chromosome in the pathogenesis of pre-eclampsia in a subgroup of patients.en_US
dc.description.provenanceMade available in DSpace on 2015-07-28T11:58:04Z (GMT). No. of bitstreams: 1 10.1007-s00439-006-0281-3.pdf: 293769 bytes, checksum: ba31448db39e048863697c1631ddab02 (MD5)en
dc.identifier.doi10.1007/s00439-006-0281-3en_US
dc.identifier.issn0340-6717
dc.identifier.urihttp://hdl.handle.net/11693/11566
dc.language.isoEnglishen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s00439-006-0281-3en_US
dc.source.titleHuman Geneticsen_US
dc.subjectRecurrent Spontaneous-abortionen_US
dc.subjectGenome-wide Scanen_US
dc.subjectFemale Predispositionen_US
dc.subjectHigh-frequencyen_US
dc.subjectWomenen_US
dc.subjectAutoimmuneen_US
dc.subjectPatternsen_US
dc.subjectDiseaseen_US
dc.subjectSelectionen_US
dc.subjectRatiosen_US
dc.titleExtremely skewed X-chromosome inactivation is increased in pre-eclampsiaen_US
dc.typeArticleen_US

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