An integrated genomic and metabolomic approach for defining survival time in adult oligodendrogliomas patients

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buir.contributor.authorÇiçek, A. Ercüment
dc.citation.epage69-11en_US
dc.citation.spage69-1en_US
dc.citation.volumeNumber15en_US
dc.contributor.authorBund, C.en_US
dc.contributor.authorGuergova‑Kuras, M.en_US
dc.contributor.authorÇiçek, A. Ercümenten_US
dc.contributor.authorMoussallieh, F.-M.en_US
dc.contributor.authorDali‑Youcef, N.en_US
dc.contributor.authorPiotto, M.en_US
dc.contributor.authorSchneider, P.en_US
dc.contributor.authorHeller, R.en_US
dc.contributor.authorEntz‑Werle, N.en_US
dc.contributor.authorLhermitte, B.en_US
dc.contributor.authorChenard, M.-P.en_US
dc.contributor.authorSchott, R.en_US
dc.contributor.authorProust, F.en_US
dc.contributor.authorNoel, G.en_US
dc.contributor.authorNamer, I. J.en_US
dc.date.accessioned2020-02-03T11:05:47Z
dc.date.available2020-02-03T11:05:47Z
dc.date.issued2019
dc.departmentDepartment of Computer Engineeringen_US
dc.description.abstractIntroduction The identification of frequent acquired mutations shows that patients with oligodendrogliomas have divergent biology with differing prognoses regardless of histological classification. A better understanding of molecular features as well as their metabolic pathways is essential. Objectives The aim of this study was to examine the relationship between the tumor metabolome, six genomic aberrations (isocitrate dehydrogenase1 [IDH1] mutation, 1p/19q codeletion, tumor protein p53 [TP53] mutation, O6-methylguanin-DNA methyltransferase [MGMT] promoter methylation, epidermal growth factor receptor [EGFR] amplification, phosphate and tensin homolog [PTEN] methylation), and the patients’ survival time. Methods We applied 1H high-resolution magic-angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy to 72 resected oligodendrogliomas. Results The presence of IDH1, TP53, 1p19q codeletion, MGMT promoter methylation reduced the relative risk of death, whereas PTEN methylation and EGFR amplification were associated with poor prognosis. Increased concentration of 2-hydroxyglutarate (2HG), N-acetyl-aspartate (NAA), myo-inositol and the glycerophosphocholine/phosphocholine (GPC/ PC) ratio were good prognostic factors. Increasing the concentration of serine, glycine, glutamate and alanine led to an increased relative risk of death. Conclusion HRMAS NMR spectroscopy provides accurate information on the metabolomics of oligodendrogliomas, making it possible to find new biomarkers indicative of survival. It enables rapid characterization of intact tissue and could be used as an intraoperative method.en_US
dc.description.provenanceSubmitted by Zeynep Aykut (zeynepay@bilkent.edu.tr) on 2020-02-03T11:05:47Z No. of bitstreams: 1 An_integrated_genomic_and_metabolomic_approach_for_defining_survival_time_in_adult_oligodendrogliomas_patients.pdf: 2366257 bytes, checksum: 1518f440bfcc7b32d8bfc9693db2062a (MD5)en
dc.description.provenanceMade available in DSpace on 2020-02-03T11:05:47Z (GMT). No. of bitstreams: 1 An_integrated_genomic_and_metabolomic_approach_for_defining_survival_time_in_adult_oligodendrogliomas_patients.pdf: 2366257 bytes, checksum: 1518f440bfcc7b32d8bfc9693db2062a (MD5) Previous issue date: 2019en
dc.identifier.doi10.1007/s11306-019-1522-5en_US
dc.identifier.issn1573-3882
dc.identifier.urihttp://hdl.handle.net/11693/52993
dc.language.isoEnglishen_US
dc.publisherSpringeren_US
dc.relation.isversionofhttps://dx.doi.org/10.1007/s11306-019-1522-5en_US
dc.source.titleMetabolomicsen_US
dc.subjectHRMAS-NMR spectroscopyen_US
dc.subjectMetabolomicsen_US
dc.subjectOligodendrogliomaen_US
dc.subjectOverall survivalen_US
dc.subjectIDHen_US
dc.subjectPTENen_US
dc.titleAn integrated genomic and metabolomic approach for defining survival time in adult oligodendrogliomas patientsen_US
dc.typeArticleen_US

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