Environmental effect and genetic influence: A regional cancer predisposition survey in the Zonguldak region of Northwest Turkey

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dc.citation.epage409en_US
dc.citation.issueNumber2en_US
dc.citation.spage391en_US
dc.citation.volumeNumber54en_US
dc.contributor.authorKadir, S.en_US
dc.contributor.authorÖnen-Hall, A. P.en_US
dc.contributor.authorAydin, S. N.en_US
dc.contributor.authorYakicier, C.en_US
dc.contributor.authorAkarsu, N.en_US
dc.contributor.authorTuncer, M.en_US
dc.date.accessioned2016-02-08T10:10:06Z
dc.date.available2016-02-08T10:10:06Z
dc.date.issued2008en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractThe Cretaceous-Eocene volcano-sedimentary units of the Zonguldak region of the western Black Sea consist of subalkaline andesite and tuff, and sandstone dominated by smectite, kaolinite, accessory chlorite, illite, mordenite, and analcime associated with feldspar, quartz, opal-CT, amphibole, and calcite. Kaolinization, chloritization, sericitization, albitization, Fe-Ti-oxidation, and the presence of zeolite, epidote, and illite in andesitic rocks and tuffaceous materials developed as a result of the degradation of a glass shards matrix, enclosed feldspar, and clinopyroxene-type phenocrysts, due to alteration processes. The association of feldspar and glass with smectite and kaolinite, and the suborientation of feldspar-edged, subparallel kaolinite plates to fracture axes may exhibit an authigenic smectite or kaolinite. Increased alteration degree upward in which Al, Fe, and Ti are gained, and Si, Na, K, and Ca are depleted, is due to the alteration following possible diagenesis and hydrothermal activities. Micromorphologically, fibrous mordenite in the altered units and the presence of needle-type chrysotile in the residential buildings in which cancer cases lived were detected. In addition, the segregation pattern of cancer susceptibility in the region strongly suggested an environmental effect and a genetic influence on the increased cancer incidence in the region. The most likely diagnosis was Li-Fraumeni syndrome, which is one of the hereditary cancer predisposition syndromes; however, no mutations were observed in the p53 gene, which is the major cause of Li-Fraumeni syndrome. The micromorphology observed in the altered units in which cancer cases were detected may have a role in the expression of an unidentified gene, but does not explain alone the occurrence of cancer as a primary cause in the region. © 2007 Springer-Verlag.en_US
dc.identifier.doi10.1007/s00254-007-0826-3en_US
dc.identifier.issn0943-0105
dc.identifier.urihttp://hdl.handle.net/11693/23189
dc.language.isoEnglishen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s00254-007-0826-3en_US
dc.source.titleEnvironmental Geologyen_US
dc.subjectAlteration mineralsen_US
dc.subjectGenetic influenceen_US
dc.subjectGeochemistryen_US
dc.subjectHealth effectsen_US
dc.subjectMineralogyen_US
dc.subjectTurkeyen_US
dc.subjectVolcanosedimentary unitsen_US
dc.subjectZonguldaken_US
dc.subjectDiagnosisen_US
dc.subjectGenesen_US
dc.subjectHealth hazardsen_US
dc.titleEnvironmental effect and genetic influence: A regional cancer predisposition survey in the Zonguldak region of Northwest Turkeyen_US
dc.typeArticleen_US

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