Perisylvian GABA levels in schizophrenia and bipolar disorder

Date
2017
Authors
Atagün, M. İ.
Şıkoglu, M. E.
Soykan, Ç.
Can, S. S.
Ulusoy-Kaymak S.
Çayköylü, A.
Algın O.
Phillips, M. L.
Öngür, D.
Moore, C. M.
Advisor
Instructor
Source Title
Neuroscience Letters
Print ISSN
0304-3940
Electronic ISSN
Publisher
Elsevier Ireland Ltd
Volume
637
Issue
Pages
70 - 74
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

The aim of this study is to measure GABA levels of perisylvian cortices in schizophrenia and bipolar disorder patients, using proton magnetic resonance spectroscopy (1H-MRS). Patients with schizophrenia (n = 25), bipolar I disorder (BD-I; n = 28) and bipolar II disorder (BD-II; n = 20) were compared with healthy controls (n = 30).1H-MRS data was acquired using a Siemens 3 T whole body scanner to quantify right and left perisylvian structures’ (including superior temporal lobes) GABA levels. Right perisylvian GABA values differed significantly between groups [χ2= 9.62, df: 3, p = 0.022]. GABA levels were significantly higher in the schizophrenia group compared with the healthy control group (p = 0.002). Furthermore, Chlorpromazine equivalent doses of antipsychotics correlated with right hemisphere GABA levels (r2= 0.68, p = 0.006, n = 33). GABA levels are elevated in the right hemisphere in patients with schizophrenia in comparison to bipolar disorder and healthy controls. The balance between excitatory and inhibitory controls over the cortical circuits may have direct relationship with GABAergic functions in auditory cortices. In addition, GABA levels may be altered by brain regions of interest, psychotropic medications, and clinical stage in schizophrenia and bipolar disorder. � 2016 Elsevier Ireland Ltd

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Other identifiers
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Keywords
Auditory cortex, Bipolar disorder, GABA, Magnetic resonance spectroscopy, Schizophrenia, 4 aminobutyric acid, atypical antipsychotic agent, lithium, valproic acid, 4 aminobutyric acid, neuroleptic agent, adult, Article, auditory cortex, bipolar disorder, controlled study, female, human, major clinical study, male, neurotransmission, priority journal, proton nuclear magnetic resonance, right hemisphere, schizophrenia, suprasylvian gyrus, temporal lobe, bipolar disorder, drug effects, metabolism, middle aged, nuclear magnetic resonance spectroscopy, procedures, schizophrenia, young adult, Adult, Antipsychotic Agents, Auditory Cortex, Bipolar Disorder, Female, gamma-Aminobutyric Acid, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged, Proton Magnetic Resonance Spectroscopy, Schizophrenia, Temporal Lobe, Young Adult
Citation
Published Version (Please cite this version)