Polymorphisms in P21 (CODON 31) and P53 (CODON 72) : association with breast cancer susceptibility in the Turkish and Greek populations

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buir.advisorYuluğ, Işık G.
dc.contributor.authorÇolakoğlu, Gülsen
dc.date.accessioned2016-07-01T10:58:16Z
dc.date.available2016-07-01T10:58:16Z
dc.date.issued2003
dc.descriptionCataloged from PDF version of article.en_US
dc.description.abstractThe aim of this study was to investigate the potential association of p53 codon 72 and/or p21 codon 31 polymorphisms with increased susceptibility for breast cancer either independently or combined in the Turkish and Greek populations. A case-control study was conducted for both populations and the genotypes of the subjects were determined by PCR-RFLP (Turkish; p53 genotypes for 274 cases and 221 controls, p21 genotypes for 322 cases and 246 controls, Greek; p53 genotypes for 138 cases and 138 controls, p21 genotypes for 156 cases and 136 controls were obtained). Binary logistic regression was used to analyze the data. Although the Greek study population alone did not give statistically significant results, the p53 codon 72 Arg/Arg inheritance was found to be significantly associated with breast cancer susceptibility in the Turkish study population (OR=2.16; 95% CI=1.08-4.31) as well as in the combined population of Turkish and Greek subjects (OR=2.35; 95% CI=1.25-4.41). This association was further increased with increased BMI (OR=3.86; 95% CI=1.12-13.26) in the Turkish population but the result should be treated with caution because of the wide confidence interval. The inheritance of the combined p21 codon 31 Arg/Arg or Ser/Arg genotypes increased breast cancer susceptibility in the Turkish study population (OR=1.15; 95% CI=0.75-1.76) although the result is not statistically significant. The most prominent result of this study is that there is an interaction between the p53 Arg72Arg and p21 Arg31Arg or Ser31Arg genotypes for breast cancer susceptibility (OR=2.66; 95% CI=1.06- 6.66). These results let us to conclude that there is a strong association between the p53 Arg72Arg genotype and breast cancer risk in the Turkish population and that the combination of high-risk allelic variants of both p53 and its downstream effector protein p21 may have a role as a risk factor for breast cancer development.en_US
dc.description.provenanceMade available in DSpace on 2016-07-01T10:58:16Z (GMT). No. of bitstreams: 1 0002349.pdf: 2428851 bytes, checksum: 3a29d275a97f20d4fef906648d06effd (MD5) Previous issue date: 2003en
dc.description.statementofresponsibilityÇolakoğlu, Gülsenen_US
dc.format.extentxiii, 121 leaves, graphs, tables, 30 cmen_US
dc.identifier.itemidBILKUTUPB071915
dc.identifier.urihttp://hdl.handle.net/11693/29347
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject.lccWP870 .C65 2003en_US
dc.subject.lcshBreast Cancer Genetic aspects.en_US
dc.titlePolymorphisms in P21 (CODON 31) and P53 (CODON 72) : association with breast cancer susceptibility in the Turkish and Greek populationsen_US
dc.typeThesisen_US
thesis.degree.disciplineMolecular Biology and Genetics
thesis.degree.grantorBilkent University
thesis.degree.levelMaster's
thesis.degree.nameMS (Master of Science)

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