Metal ion release and signaling in molecular logic gate design

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buir.advisorAkkaya, Engin U.
dc.contributor.authorUyar, Taha Bilal
dc.date.accessioned2016-11-03T06:37:08Z
dc.date.available2016-11-03T06:37:08Z
dc.date.copyright2016-10
dc.date.issued2016-10
dc.date.submitted2016-11-01
dc.departmentGraduate Program in Materials Science and Nanotechnologyen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (Ph. D.) : Bilkent University, Department of Materials Science and Nanotechnology, İhsan Doğramacı Bilkent University, 2016.en_US
dc.descriptionIncludes bibliographical references (leaves 155-176).en_US
dc.description.abstractMimicking the biological structures is one of the main goals of the natural sciences, because processes are well-organized in nature despite its amazing complexity. On account of this, releasing metal ions at molecular level is a crucial topic owing to similar process in living organisms. In this thesis, we designed novel cage compounds for this purpose. Our novel cage molecule is activated with near-IR light while almost all of the cage compounds in the previous literature function in the UV region. Consequently, it is appropriate for using in biological systems. Release of zinc ions that has critical roles in human body successfully achieved by our novel compound in Part 2 of the thesis work. Molecular logic concept is one of the promising areas of chemistry. Today, electronic devices consists of silicon based circuits that process information by using binary logic. Molecular logic offers alternative for silicon based devices. Using molecules to process data is a promising idea in the fields from electronics to biotechnology. In part 3, we proposed AND gate whose inputs are pH and glutathione while the response is singlet oxygen which can be used to destroy cancer cells. It is possible to process much complicated information by combining more than one logic gate. In first part of the thesis study, we designed modular molecular logic gates by cascading of three logic gates via metal ion signals. In the last part, a fluorescent chemosensor was proposed for dopamine molecule, which is crucial in a number of biological processes at the human body.en_US
dc.description.degreePh.D.en_US
dc.description.statementofresponsibilityby Taha Bilal Uyar.en_US
dc.embargo.release2019-10-27
dc.format.extentxvii, 238 leaves : illustrations (some color), charts.en_US
dc.identifier.itemidB123664
dc.identifier.urihttp://hdl.handle.net/11693/32510
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMolecular logic gateen_US
dc.subjectCage compoundsen_US
dc.subjectFluorescenceen_US
dc.subjectGlutathioneen_US
dc.subjectPhotosensitizeren_US
dc.subjectMetal ion releaseen_US
dc.subjectBODIPYen_US
dc.subjectDopamineen_US
dc.titleMetal ion release and signaling in molecular logic gate designen_US
dc.title.alternativeMetal iyonu salımı ve moleküler mantık devrelerinde sinyalizasyonen_US
dc.typeThesisen_US

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