Coagulation factor V gene mutation increases the risk of venous thrombosis in Behcet's disease

Date
1996
Authors
Gül, A.
Özbek, U.
Öztürk, C.
Inanç, M.
Koniçe, M.
Özçelik, T.
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Source Title
British Journal of Rheumatology
Print ISSN
0263-7103
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Publisher
Oxford University Press
Volume
35
Issue
11
Pages
1178 - 1180
Language
English
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Abstract

We investigated the prevalence of the coagulation factor V gene G1691A mutation in 64 patients with Behcet's disease (BD) and in 107 apparently healthy individuals. The mutation was present in the heterozygous state in 37.5% of the patients with a history of deep vein thrombosis (12/32) and in 9.4% of the patients without any thrombotic event (3/32). Eleven healthy individuals were also heterozygous for the mutation (10.3%). The prevalence of the mutation in BD patients with and without thrombosis was significantly different (P = 0.0079). We conclude that the factor V gene mutation may play a major role in the development of venous thrombosis in BD.

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Published Version (Please cite this version)