Identification of novel apoptotic markers based on hybridoma technology

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buir.advisorYağcı, Tamer
dc.contributor.authorÇıracı, Ceren
dc.date.accessioned2016-01-08T20:17:56Z
dc.date.available2016-01-08T20:17:56Z
dc.date.issued2004
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.descriptionAnkara : The Department of Moleculer Biology and Genetics and the Institute of Engineering and Science of Bilkent Univ., 2004.en_US
dc.descriptionThesis (Master's) -- Bilkent University, 2004.en_US
dc.descriptionIncludes bibliographical refences.en_US
dc.description.abstractApoptosis is a physiological cell death program that is characterized by morphological changes such as nuclear condensation, membrane blebbing, cell shrinkage, DNA cleavage and formation of apoptotic bodies. It is required for normal development and maintenance of cellular homeostasis and dysregulation of apoptosis leads to several developmental abnormalities, progression of degenerative diseases and cancer development. Elucidating the mechanisms underlying this form of cell death and development of molecular markers for its identification are of great importance to understand tumorigenesis. One way to generate molecular markers is based on monoclonal antibodyproduction. Utilization of such antibodies as apoptotic markers is strictly dependent on their molecular specificity and selectivity in terms of recognizing targeted proteins. We produced monoclonal antibodies by using apoptotic Huh-7 hepatocellular carcinoma cells as immunogen, and chose two of them, namely 9C11 and 6D5 for further characterization in the context of apoptosis.en_US
dc.description.degreeM.S.en_US
dc.description.provenanceMade available in DSpace on 2016-01-08T20:17:56Z (GMT). No. of bitstreams: 1 1.pdf: 78510 bytes, checksum: d85492f20c2362aa2bcf4aad49380397 (MD5)en
dc.description.statementofresponsibilityÇıracı, Cerenen_US
dc.format.extentxii, 63 leaves, illustrationsen_US
dc.identifier.urihttp://hdl.handle.net/11693/18287
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject.lccQH671 .C47 2004en_US
dc.subject.lcshApoptosis--Immunology.en_US
dc.subject.lcshHybridomas.en_US
dc.titleIdentification of novel apoptotic markers based on hybridoma technologyen_US
dc.typeThesisen_US

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