A new set of monoclonal antibodies directed to proline-rich and central regions of p53

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dc.citation.epage292en_US
dc.citation.issueNumber5en_US
dc.citation.spage287en_US
dc.citation.volumeNumber23en_US
dc.contributor.authorVoeltzel, T.en_US
dc.contributor.authorMorel, A. P.en_US
dc.contributor.authorRostan, M. C.en_US
dc.contributor.authorJi, J.en_US
dc.contributor.authorChiodino, C.en_US
dc.contributor.authorPonchel, F.en_US
dc.contributor.authorVigouroux, J.en_US
dc.contributor.authorDe Fromentel, C. C.en_US
dc.contributor.authorSoussi, T.en_US
dc.contributor.authorOzturk, M.en_US
dc.date.accessioned2016-02-08T10:25:44Z
dc.date.available2016-02-08T10:25:44Z
dc.date.issued2004en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractThe p53 protein can adopt several conformations in cells - "latent," "active," or mutant - depending on cellular stress or mutations of the TP53 gene. Today, only a few antibodies discriminating these conformations are available. We produced three new anti-p53 monoclonal antibodies (MAbs) directed against epitopes of human p53. The H53C1 MAb recognizes an epitope located at the N-terminal part of the central region of p53 and can discriminate mutant from wild-type conformation. The H53C2 and H53C3 MAbs are against different epitopes within the proline-rich region of p53. Moreover, the H53C2 epitope is located in the second negative regulatory domain of p53 between residues 80 and 93. These MAbs can be used as new tools to study and modulate the cellular functions of p53.en_US
dc.identifier.doi10.1089/hyb.2004.23.287en_US
dc.identifier.issn1536-8599
dc.identifier.urihttp://hdl.handle.net/11693/24212
dc.language.isoEnglishen_US
dc.publisherMary Ann Liebert, Inc.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1089/hyb.2004.23.287en_US
dc.source.titleHybridoma and Hybridomicsen_US
dc.subjectEpitopeen_US
dc.subjectMonoclonal antibodyen_US
dc.subjectmonoclonal antibody h53c1en_US
dc.subjectmonoclonal antibody h53c2en_US
dc.subjectMonoclonal antibody h53c3en_US
dc.subjectProlineen_US
dc.subjectProtein p53en_US
dc.subjectUnclassified drugen_US
dc.subjectAmino terminal sequenceen_US
dc.subjectAnimal cellen_US
dc.subjectAntibody productionen_US
dc.titleA new set of monoclonal antibodies directed to proline-rich and central regions of p53en_US
dc.typeArticleen_US

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