Genetic aspects of hepatocellular carcinogenesis

Simple item page
dc.citation.epage242en_US
dc.citation.issueNumber3en_US
dc.citation.spage235en_US
dc.citation.volumeNumber19en_US
dc.contributor.authorOzturk, M.en_US
dc.date.accessioned2016-02-08T10:40:38Z
dc.date.available2016-02-08T10:40:38Z
dc.date.issued1999en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractHepatocellular carcinoma (HCC) is linked etiologically to viruses (hepatitis B virus [HBV] and hepatitis C virus [HCV]), chemical carcinogens (i.e., aflatoxins), and other environmental and host factors causing chronic liver injury. Some hepatoblastomas may be linked to inherited gene mutations, but adult hereditary HCC appears to be rare. HCCs display gross genomic alterations, including DNA rearrangements associated with HBV DNA integration, loss of heterozygosity, and, less importantly, chromosomal amplifications and loss of imprinting. Many genes with somatic mutations have now been identified in these tumors. Most frequently involved genes are tumor suppressor genes such as p53, M6P/IGF2R, β-catenin, p16INK4A, and retinoblastoma genes. Most identified mutations are somatic, but germline mutations of p16INK4A, APC, and BRCA2 have also been reported. Oncogenic activation of several cellular genes such as cyclin D and cyclin A have been described in HCC, but the possible implication of candidate viral oncogenes (i.e., X protein of HBV) is still debated. A comprehensive analysis of all the genetic changes described for HCC demonstrates that at least four different growth regulatory pathways are altered in these tumors. However, each pathway appears to be implicated in a limited fraction of these tumors, suggesting that HCCs are genetically heterogenous neoplasms. This genetic heterogeneity correlates with the heterogeneity of etiologic factors implicated in HCC.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:40:38Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 1999en
dc.identifier.issn0272-8087
dc.identifier.urihttp://hdl.handle.net/11693/25189
dc.language.isoEnglishen_US
dc.source.titleSeminars in Liver Diseaseen_US
dc.subjectβ- cateninen_US
dc.subjectCyclin Den_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectM6P/IGF2Ren_US
dc.subjectP16INK4Aen_US
dc.subjectp53en_US
dc.subjectPrimary liver canceren_US
dc.subjectAflatoxinen_US
dc.subjectBeta cateninen_US
dc.subjectCarcinogenen_US
dc.subjectCyclin aen_US
dc.subjectCyclin den_US
dc.subjectProtein p53en_US
dc.subjectGene mutationen_US
dc.subjectHepatitis b virusen_US
dc.subjectHepatitis c virusen_US
dc.titleGenetic aspects of hepatocellular carcinogenesisen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Genetic aspects of hepatocellular carcinogenesis.pdf
Size:
738.28 KB
Format:
Adobe Portable Document Format
Description:
Full printable version
Download

Collections

Department of Molecular Biology and Genetics