Arithmetic and temporal transformations of working memory activation in subjects prone to psychosis

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buir.advisorToulopoulou, Timothea
dc.contributor.authorBaş, Timuçin
dc.date.accessioned2018-09-24T13:58:12Z
dc.date.available2018-09-24T13:58:12Z
dc.date.copyright2018-09
dc.date.issued2018-09
dc.date.submitted2018-09-24
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (M.S.): Bilkent University, Department of Neuroscience, İhsan Doğramacı Bilkent University, 2018.en_US
dc.descriptionIncludes bibliographical references (leaves 36-51).en_US
dc.description.abstractWorking memory (WM) deficit is a well-studied cognitive impairment in psychosis which is stemming from various developmental abnormalities containing neurobiological heterogeneity. Recently, many studies have concluded that the WM impairment is a symptom which manifests itself before the onset of the disorder, but these studies mostly focused on the individuals at clinically high risk. The mild proneness to psychosis which develops during the adolescent period is not well understood and how the working memory is affected due to mild proneness to psychosis has not been elucidated heretofore. In this research, we aimed to examine the association between the mild proneness to psychosis and working memory processing. Thirty-two individuals were split in half as mildly prone to psychosis and not prone to psychosis based on the Structured Interview for Schizotypy (SIS-R). Each participant performed a robust working memory task which consists of computational and temporally varying information loads. The data were collected via a magnetic resonance imaging (MRI) scanner and analysed by applying a general linear model to detect altered working memory activations due to proneness to psychosis. We have observed that the processes requiring manipulation and rapid updating of the information are associated with a large network of prefrontal cortex and superior parietal lobule. The finding of this study suggests that the mild proneness to psychosis has affected the working memory weakly and that the alterations demonstrated in the prefrontal cortex and parietal lobules may be clinically relevant to psychosis.en_US
dc.description.provenanceSubmitted by Betül Özen (ozen@bilkent.edu.tr) on 2018-09-24T13:58:12Z No. of bitstreams: 1 Timuçin Baş 10212800.pdf: 10003204 bytes, checksum: 46d619664cc403e33f298b96fabba4f9 (MD5)en
dc.description.provenanceMade available in DSpace on 2018-09-24T13:58:12Z (GMT). No. of bitstreams: 1 Timuçin Baş 10212800.pdf: 10003204 bytes, checksum: 46d619664cc403e33f298b96fabba4f9 (MD5) Previous issue date: 2018-09en
dc.description.statementofresponsibilityby Timothea Toulopoulou.en_US
dc.format.extentx, 62 leaves : illustrations (some color), tables ; 30 cm.en_US
dc.identifier.itemidB159023
dc.identifier.urihttp://hdl.handle.net/11693/47968
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectWorking Memoryen_US
dc.subjectPsychosisen_US
dc.subjectfMRIen_US
dc.titleArithmetic and temporal transformations of working memory activation in subjects prone to psychosisen_US
dc.title.alternativePsikoza yatkın bireylerde çalışma belleği aktivasyonunun aritmetik ve zamana bağlı dönüşümlerien_US
dc.typeThesisen_US
thesis.degree.disciplineNeuroscience
thesis.degree.grantorBilkent University
thesis.degree.levelMaster's
thesis.degree.nameMS (Master of Science)

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