3-Propionyl-thiazolidine-4-carboxylic acid ethyl esters: A family of antiproliferative thiazolidines

dc.citation.epage93en_US
dc.citation.issueNumber1en_US
dc.citation.spage90en_US
dc.citation.volumeNumber6en_US
dc.contributor.authorÖnen-Bayram F.E.en_US
dc.contributor.authorBuran, K.en_US
dc.contributor.authorDurmaz I.en_US
dc.contributor.authorBerk, B.en_US
dc.contributor.authorCetin-Atalay, R.en_US
dc.date.accessioned2016-02-08T10:14:23Z
dc.date.available2016-02-08T10:14:23Z
dc.date.issued2015en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractCancer results from unregulated cell growth. Reactivating the process of the programmed cell death, i.e. apoptosis, is a classical anticancer therapeutic strategy. The apoptosis-inducing property of the (2RS,4R)-2-phenyl-3-propionyl-thiazolidine-4-carboxylic acid ethyl ester (ALC 67) molecule has recently been discovered. We analyzed in this study the impact of the phenyl moiety of this molecule on its biological activity by synthesizing and evaluating analogues where this substituent was replaced by a series of aromatic and aliphatic groups. The results demonstrated that the molecule's antiproliferative property resisted such modifications. Thus, in addition to developing a family of thiazolidine compounds with promising anticancer properties; our investigation revealed that the second position of the thiazolidine ring can be used either to tune the physicochemical properties of ALC67 or to introduce a fluorescent tag to the structure in order to track it in cells and determine its exact molecular mechanism of action. © 2015 The Royal Society of Chemistry.en_US
dc.identifier.doi10.1039/c4md00306cen_US
dc.identifier.issn20402503
dc.identifier.urihttp://hdl.handle.net/11693/23469
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c4md00306cen_US
dc.source.titleMedChemCommen_US
dc.subject2 phenyl 3 propionylthiazolidine 4 carboxylic acid ethyl esteren_US
dc.subject3 propionylthiazolidine 4 carboxylic acid ethyl ester derivativeen_US
dc.subjectcamptothecinen_US
dc.subjectfluorouracilen_US
dc.subjectthiazolidine derivativeen_US
dc.subjectunclassified drugen_US
dc.subjectantineoplastic activityen_US
dc.subjectArticleen_US
dc.subjectchemical modificationen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug cytotoxicityen_US
dc.subjectdrug structureen_US
dc.subjectdrug synthesisen_US
dc.subjecthepatocellular carcinoma cell lineen_US
dc.subjectIC50en_US
dc.subjectphysical chemistryen_US
dc.title3-Propionyl-thiazolidine-4-carboxylic acid ethyl esters: A family of antiproliferative thiazolidinesen_US
dc.typeArticleen_US
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