Design, synthesis and characterization of activatable photosensitizers for photodynamic therapy

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buir.advisorAkkaya, Engin U.
dc.contributor.authorÇakmak, Fatma Pir
dc.date.accessioned2016-01-08T18:19:11Z
dc.date.available2016-01-08T18:19:11Z
dc.date.issued2012
dc.departmentDepartment of Chemistryen_US
dc.descriptionAnkara : The Department of Chemistry and the Graduate School of Engineering and Science of Bilkent University, 2012.en_US
dc.descriptionThesis (Master's) -- Bilkent University, 2012.en_US
dc.descriptionIncludes bibliographical references leaves 56-69.en_US
dc.description.abstractSearch for new noninvasive methods for diseases has been significant question for years. Therapeutic properties of light are combined with proper chromophore in order to create fundamentals of photodynamic therapy which is a new treatment modality for cancer and other various non-oncological diseases. The method relies on the activation of photosensitizer by using light of certain wavelength and generation of cytotoxic singlet oxygen species in response. Reactive oxygen species kill the targeted tissue within smaller effective diameter through apoptosis/ necrosis mechanism. Through this method, new PDT agents can be proposed and their properties can be tuned by manipulation of other photophysical processes. In this thesis, synthesis, characterization novel water soluble, near IR absorbing Bodipy photosensitizer will be discussed. As opposed to other photosensitizers in literature, this photosensitizer is rationally designed to have singlet oxygen generation capability only in cancer tissue as a result of glutathione triggered activation.en_US
dc.description.degreeM.S.en_US
dc.description.statementofresponsibilityÇakmak, Fatma Piren_US
dc.format.extentxii, 94 leaves, illustrationsen_US
dc.identifier.itemidB133815
dc.identifier.urihttp://hdl.handle.net/11693/15481
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBodipyen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectGlutathioneen_US
dc.subjectWater solubleen_US
dc.subject.lccQZ267 .C45 2012en_US
dc.subject.lcshPhotochemotherapy.en_US
dc.subject.lcshPhotosensitizing Agents--therapeutic use.en_US
dc.subject.lcshNanostructured materials.en_US
dc.subject.lcshPhototherapy.en_US
dc.titleDesign, synthesis and characterization of activatable photosensitizers for photodynamic therapyen_US
dc.typeThesisen_US
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