What does reduced FDG uptake mean in high-grade gliomas?

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buir.contributor.authorÇiçek, A. Ercüment
dc.citation.epage942en_US
dc.citation.issueNumber12en_US
dc.citation.spage936en_US
dc.citation.volumeNumber44en_US
dc.contributor.authorBund, C.en_US
dc.contributor.authorLhermitte, B.en_US
dc.contributor.authorÇiçek, A. Ercümenten_US
dc.contributor.authorRuhland, E.en_US
dc.contributor.authorProust, F.en_US
dc.contributor.authorNamer, I. J.en_US
dc.date.accessioned2020-02-11T10:41:24Z
dc.date.available2020-02-11T10:41:24Z
dc.date.issued2019
dc.departmentDepartment of Computer Engineeringen_US
dc.description.abstractPurpose: As well as in many others cancers, FDG uptake is correlated with the degree of malignancy in gliomas, that is, commonly high FDG uptake in high-grade gliomas. However, in clinical practice, it is not uncommon to observe high-grade gliomas with low FDG uptake. Our aim was to explore the tumor metabolism in 2 populations of high-grade gliomas presenting high or low FDG uptake. Methods: High-resolution magic-angle spinning nuclear magnetic resonance spectroscopy was realized on tissue samples from 7 high-grade glioma patients with high FDG uptake and 5 high-grade glioma patients with low FDG uptake. Tumor metabolomics was evaluated from 42 quantified metabolites and compared by network analysis. Results: Whether originating from astrocytes or oligodendrocytes, the highgrade gliomas with low FDG avidity represent a subgroup of high-grade gliomas presenting common characteristics: low aspartate, glutamate, and creatine levels, which are probably related to the impaired electron transport chain in mitochondria; high serine/glycine metabolism and so one-carbon metabolism; low glycerophosphocholine-phosphocholine ratio in membrane metabolism, which is associated with tumor aggressiveness; and finally negative MGMT methylation status. Conclusions: It seems imperative to identify this subgroup of high-grade gliomas with low FDG avidity, which is especially aggressive. Their identification could be important for early detection for a possible personalized treatment, such as antifolate treatment.en_US
dc.description.provenanceSubmitted by Evrim Ergin (eergin@bilkent.edu.tr) on 2020-02-11T10:41:24Z No. of bitstreams: 1 What_Does_Reduced_FDG_Uptake_Mean_in_High-Grade_Gliomas.pdf: 1066015 bytes, checksum: 8f8907911c3ddd4612d66a55ee1ae6b5 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-02-11T10:41:24Z (GMT). No. of bitstreams: 1 What_Does_Reduced_FDG_Uptake_Mean_in_High-Grade_Gliomas.pdf: 1066015 bytes, checksum: 8f8907911c3ddd4612d66a55ee1ae6b5 (MD5) Previous issue date: 2019-12en
dc.identifier.doi10.1097/RLU.0000000000002765en_US
dc.identifier.eissn1536-0229
dc.identifier.urihttp://hdl.handle.net/11693/53262
dc.language.isoEnglishen_US
dc.publisherNLM (Medline)en_US
dc.relation.isversionofhttps://dx.doi.org/10.1097/RLU.0000000000002765en_US
dc.source.titleClinical Nuclear Medicineen_US
dc.subjectFDG PETen_US
dc.subjectGliomaen_US
dc.subjectMetabolomicsen_US
dc.subjectHRMAS-NMR spectroscopyen_US
dc.titleWhat does reduced FDG uptake mean in high-grade gliomas?en_US
dc.typeArticleen_US

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